Fosnetupitant Explained

Atc Prefix:None
Cas Number:1703748-89-3
Pubchem:71544786
Drugbank:DB14019
Chemspiderid:44208829
Unii:T672P80L2S
Kegg:D11065
Chembl:3989917
Synonyms:07-PNET, fosnetupitant chloride hydrochloride
C:31
H:35
F:6
N:4
O:5
P:1

Fosnetupitant is a medication used for the treatment of chemotherapy-induced nausea and vomiting. It is a prodrug of netupitant.[1] It is used in combination with palonosetron hydrochloride and formulated as the salt fosnetupitant chloride hydrochloride for intravenous use.[2]

In 2018, the US Food and Drug Administration approved the intravenous formulation of a fixed dose combination of fosnetupitant and palonosetron.[3] [4] The combination is also approved for medical use in the European Union,[5] and in Canada.[6]

Notes and References

  1. Aapro M, Jordan K, Scotté F, Celio L, Karthaus M, Roeland E . Netupitant-palonosetron (NEPA) for Preventing Chemotherapy-induced Nausea and Vomiting: From Clinical Trials to Daily Practice . Current Cancer Drug Targets . 22 . 10 . 806–824 . 2022 . 35570542 . 10.2174/1568009622666220513094352 . 9720881 . free .
  2. Web site: Fosnetupitant/Palonosetron (Intravenous Route) . Mayo Clinic . 8 June 2022 . 8 June 2022 . https://web.archive.org/web/20220608181650/https://www.mayoclinic.org/drugs-supplements/fosnetupitant-palonosetron-intravenous-route/description/drg-20425898 . live .
  3. Web site: Fosnetupitant . . 8 June 2022 . 2 December 2021 . https://web.archive.org/web/20211202130355/https://go.drugbank.com/drugs/DB14019 . live .
  4. Web site: Akynzeo- netupitant and palonosetron capsule Akynzeo- fosnetupitant and palonosetron injection . DailyMed . 28 May 2020 . 18 July 2020 . 18 October 2020 . https://web.archive.org/web/20201018154534/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8e47618e-af46-4d82-94e8-1507c042252d . live .
  5. Web site: Akynzeo EPAR . European Medicines Agency (EMA) . 23 June 2015 . 9 June 2022 . 19 March 2020 . https://web.archive.org/web/20200319201955/https://www.ema.europa.eu/en/medicines/human/EPAR/akynzeo . live .
  6. Web site: Akynzeo (netupitant/palonosetron) capsules . Product Insert . Elvium Life Sciences . 31 August 2020 . 10 June 2022 . 10 June 2022 . https://web.archive.org/web/20220610022830/https://pdf.hres.ca/dpd_pm/00057864.PDF . live .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Fosnetupitant".

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