Formate dehydrogenase (NADP+) explained

formate dehydrogenase (NADP+)
Ec Number:	1.17.1.10
Cas Number:	51377-43-6
Go Code:	0047899

In enzymology, a formate dehydrogenase (NADP+) is an enzyme that catalyzes the chemical reaction

formate + NADP⁺

\rightleftharpoons CO₂ + NADPH

Thus, the two substrates of this enzyme are formate and NADP⁺, whereas its two products are CO₂ and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is formate:NADP+ oxidoreductase. Other names in common use include NADP+-dependent formate dehydrogenase, and formate dehydrogenase (NADP+). This enzyme participates in methane metabolism. It has 3 cofactors: iron, Tungsten, and Selenium.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References

• Andreesen JR, Ljungdahl LG . 1974 . Nicotinamide adenine dinucleotide phosphate-dependent formate dehydrogenase from Clostridium thermoaceticum: purification and properties . J. Bacteriol. . 120 . 6 - 14 . 4154039 . 1 . 10.1128/JB.120.1.6-14.1974 . 245723 .
• Yamamoto I, Saiki T, Liu SM, Ljungdahl LG . 1983 . Purification and properties of NADP-dependent formate dehydrogenase from Clostridium thermoaceticum, a tungsten-selenium-iron protein . J. Biol. Chem. . 258 . 1826 - 32 . 6822536 . 3 . 10.1016/S0021-9258(18)33062-X . free .