Formate dehydrogenase-N explained

Formate dehydrogenase-N
Ec Number:	1.1.5.6

Formate dehydrogenase-N (Fdh-N, FdnGHI, nitrate-inducible formate dehydrogenase, formate dehydrogenase N, FDH-N, nitrate inducible Fdn, nitrate inducible formate dehydrogenase) is an enzyme with systematic name formate:quinone oxidoreductase.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

\rightleftharpoons CO₂ + quinol

This enzyme contains molybdopterin-guanine dinucleotides, five [4Fe-4S] clusters and two heme b groups.

Notes and References

1. Enoch HG, Lester RL . The purification and properties of formate dehydrogenase and nitrate reductase from Escherichia coli . The Journal of Biological Chemistry . 250 . 17 . 6693–705 . September 1975 . 10.1016/S0021-9258(19)40989-7 . free . 1099093 .
2. Jormakka M, Törnroth S, Byrne B, Iwata S . Molecular basis of proton motive force generation: structure of formate dehydrogenase-N . Science . 295 . 5561 . 1863–8 . March 2002 . 11884747 . 10.1126/science.1068186 . 2002Sci...295.1863J .
3. Jormakka M, Törnroth S, Abramson J, Byrne B, Iwata S . Purification and crystallization of the respiratory complex formate dehydrogenase-N from Escherichia coli . Acta Crystallographica Section D . 58 . Pt 1 . 160–2 . January 2002 . 11752799 . 10.1107/s0907444901017723 . 2002AcCrD..58..160J .