Fominoben Explained
| Tradename: | Broncomenal, Deronyl, Finaten, Noleptan, Oleptan, Terion, Tosifar, Tussirama[1] |
| Iupac Name: | N-[3-chloro-2-[<nowiki/>[methyl-(2-morpholin-4-yl-2-oxoethyl)amino]methyl]phenyl]benzamide |
| Cas Number: | 18053-31-1 |
| Pubchem: | 3407 |
| Drugbank: | DB08968 |
| Chemspiderid: | 3290 |
| Chembl: | 1697837 |
| Chebi: | 135639 |
| Kegg: | D07988 |
| Unii: | TJ2KK6NYJS |
| C: | 21 |
| H: | 24 |
| Cl: | 1 |
| N: | 3 |
| O: | 3 |
| Smiles: | CN(CC1=C(C=CC=C1Cl)NC(=O)C2=CC=CC=C2)CC(=O)N3CCOCC3 |
| Stdinchi: | 1S/C21H24ClN3O3/c1-24(15-20(26)25-10-12-28-13-11-25)14-17-18(22)8-5-9-19(17)23-21(27)16-6-3-2-4-7-16/h2-9H,10-15H2,1H3,(H,23,27) |
| Stdinchikey: | KSNNEUZOAFRTDS-UHFFFAOYSA-N |
Fominoben is an antitussive agent of the benzanilide class, formerly marketed under the name Noleptan.[2] It binds poorly to the sigma-1 receptor, a receptor activated by many other antitussives.[3] It is reported to have respiratory stimulant activity.[4] Other research has indicated it may be an agonist at the benzodiazepine site of the GABAA receptor.[5] It was introduced in Germany in 1973, in Italy in 1979, and in Japan in 1983.[6]
Adverse effects include appetite suppression, nausea, vomiting, insomnia, irritability, and hallucinations. Rarer side effects include somnolence, dizziness, dry mouth, blurred vision, and urticaria.[7]
Notes and References
- Book: Swiss Pharmaceutial Society . Index Nominum 2000: International Drug Directory . January 2000 . Taylor & Francis . 978-3-88763-075-1 . 470 .
- Web site: FOMINOBEN . March 25, 2021 . NCATS Inxight: Drugs.
- Musacchio JM, Klein M . Dextromethorphan binding sites in the guinea pig brain . Cellular and Molecular Neurobiology . 8 . 2 . 149–56 . June 1988 . 3044591 . 10.1007/BF00711241 . 33844132 .
- Sasaki T, Sugiyama M, Sasaki H, Suzuki S, Takishima T . Effects of the antitussive fominoben (PB89) on hypoxia in chronic obstructive lung disease: comparison with dextromethorphan using a double-blind method . The Journal of International Medical Research . 13 . 2 . 96–101 . 1985 . 3158563 . 10.1177/030006058501300204 . 30176251 .
- Crawley JN, Blumstein LK, Baldino F . Anxiolytic-like properties of fominoben . European Journal of Pharmacology . 97 . 3–4 . 277–81 . January 1984 . 6142823 . 10.1016/0014-2999(84)90460-6 .
- Book: William Andrew Publishing . Pharmaceutical Manufacturing Encyclopedia . 22 October 2013 . Elsevier . 978-0-8155-1856-3 . 1705–7 .
- Book: 9788448604271. Farmacología clínica y terapéutica médica. Martín. Alfonso Velasco. 2004. Tratamiento sintomático de la tos y del resfriado común. 260. McGraw-Hill/Interamericana .
