Folliculosebaceous cystic hamartoma explained

Specialty:Dermatology

Folliculosebaceous cystic hamartoma abbreviated as (FSCH) is a rare cutaneous hamartoma consisting of dilated folliculosebaceous units invested in mesenchymal elements.[1] it typically affects adults, have a predilection for the central face or scalp, with less than 1.5 cm dimension.[2] Clinically, the lesions are asymptomatic, rubbery to firm in consistency, and usually occur on or above the neck in (> 90%) of cases, Histopathologically, FSCH shares several similar features to sebaceous trichofolliculoma, but it is usually possible to differentiate these two tumors.[3]

Signs and symptoms

Folliculosebaceous cystic hamartomas frequently manifests as a flesh-colored papule or nodule that is asymptomatic. Folliculosebaceous cystic hamartomas are usually found on the scalp or central face.[4] The lesions are usually 0.5–1.5 cm flesh-colored, exophytic, solitary, rubbery or firm, and partially umbilicated.[5]

Diagnosis

The typical histopathologic features of folliculosebaceous cystic hamartoma lesions are mesenchymal, follicular, and sebaceous elements; these lesions frequently manifest as sebaceous structures that emerge from a core infundibular cyst that is contained inside the dermis.[6] Mesenchymal alterations are frequently observed throughout the stroma and are characterized by fibrillary bundles of collagen with proliferating adipocytes, as well as a rise in capillaries and tiny venules.[7] [6] There are clefts separating the neighboring dermis from the epithelial component.[6] In the stroma of lesions, immature adipocytes with lipid droplets and spindle- or starry-shaped nuclei have been observed; these cells are frequently located close to the sebaceous formations.[7]

See also

Further reading

External links

Notes and References

  1. Book: James, William D. . Berger, Timothy G. . Andrews' Diseases of the Skin: Clinical Dermatology . Saunders Elsevier . 2006 . 0-7216-2921-0 . etal.
  2. Cole P, Kaufman Y, Dishop M, Hatef DA, Hollier L . Giant, congenital folliculosebaceous cystic hamartoma: a case against a pathogenetic relationship with trichofolliculoma . . 30 . 5 . 500–3 . October 2008 . 18806500 . 10.1097/DAD.0b013e318183eb07 .
  3. Tanimura S, Arita K, Iwao F, etal . Two cases of folliculosebaceous cystic hamartoma . . 31 . 1 . 68–70 . January 2006 . 16309487 . 10.1111/j.1365-2230.2005.01974.x .
  4. Nguyen . Catherine M. . Skupsky . Hadas . Cassarino . David . Folliculosebaceous Cystic Hamartoma With Spindle Cell Lipoma-Like Stromal Features . The American Journal of Dermatopathology . Ovid Technologies (Wolters Kluwer Health) . 37 . 12 . 2015 . 0193-1091 . 10.1097/dad.0000000000000332 . e140–e142. 4894800 .
  5. Ansai . Shin-ichi . Kimura . Tetsunori . Kawana . Seiji . A Clinicopathologic Study of Folliculosebaceous Cystic Hamartoma . The American Journal of Dermatopathology . 32 . 8 . 2010 . 0193-1091 . 10.1097/DAD.0b013e3181e07824 . 815–820.
  6. Suarez‐Peñaranda . Jose M. . Vieites . Begoña . Ramírez‐Santos . Aquilina . Fernández‐Redondo . Virginia . Toribio . Jaime . Del Rio . Emilo . Forteza‐Vila . Jerónimo . Clinicopathological and immnuohistochemical findings in a series of folliculosebaceous cystic hamartoma . Journal of Cutaneous Pathology . Wiley . 36 . 2 . 2009-01-20 . 0303-6987 . 10.1111/j.1600-0560.2008.01011.x . 251–256.
  7. Misago . Noriyuki . Kimura . Tetsunori . Toda . Shuji . Mori . Toru . Narisawa . Yutaka . A Revaluation of Folliculosebaceous Cystic Hamartoma: The Histopathological and Immunohistochemical Features . The American Journal of Dermatopathology . Ovid Technologies (Wolters Kluwer Health) . 32 . 2 . 2010 . 0193-1091 . 10.1097/dad.0b013e3181a9de8c . 154–161.

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