Folate-binding protein explained

Folate-binding protein (FBP) are proteins that bind folate, typically the folate receptors and reduced folate carrier.^[1]

FBP can be a marker for ovarian cancer.^[2]

FBP can be measured to help in tumour classification to aid treatment, as it is over-expressed (20-80 fold) in more than 90% of ovarian and endometrial cancers, as well as 20-50% of breast, lung, colorectal, and renal cell carcinomas. FBP has very limited tissue distribution and expression in non-malignant tissue, making it a good immunotherapy target.^[3]

Alternative usage

FBP can refer to protein(s) (e.g. extracted from cow's milk) used to do folic acid assays.^[4]

Notes and References

1. The role of folate receptor a in cancer development, progression and treatment: Cause, consequence or innocent bystander? . 2006 . 10.1002/ijc.21712 . 16453285 . 119 . 2 . Int. J. Cancer . 243–50. Kelemen. L. E.. free .
2. Folate-binding Protein Is a Marker for Ovarian Cancer . Cancer Research . 51 . 19 . 5329–5338 . 1991 . Trowsdale . John . Foulkes . William D. . Jones . Tania A. . Campbell . Ian G. . 1717147 .
3. http://www.marketwatch.com/story/galena-biopharma-to-present-at-the-10th-annual-biotechnology-investor-forum-2011-10-21
4. Sobczyńska-Malefora A, Harrington DJ . Laboratory assessment of folate (vitamin B9) status . Journal of Clinical Pathology . 71 . 11 . 949–956 . November 2018 . 30228213 . 10.1136/jclinpath-2018-205048 . 52297720 .