Heck's disease explained

Synonym:	Multifocal epithelial hyperplasia

Heck's disease, also known as Focal Epithelial Hyperplasia, is an asymptomatic, benign neoplastic condition characterized by multiple white to pinkish papules that occur diffusely in the oral cavity.^{[1] [2]} Can present with slightly pale, smooth or roughened surface morphology. It is caused by the human papilloma virus types 13 and 32.^[3] It exhibits surface cells with vacuolated cytoplasm around irregular, pyknotic nuclei and occasional cells with mitosis-like changes within otherwise mature and well-differentiated epithelium. A distinguishing histologic feature is elongated rete ridges with mitosoid bodies. It shows 'cobblestone' appearance clinically. It was first identified in the Aboriginal population of North America.^[4]

Over time, they will spontaneously regress without treatment.^[5] Possible treatment may be excisional biopsy for lesions of functional or aesthetic concern.

Notes and References

1. Tenore. G.. Palaia. G.. Del Vecchio. A.. Galanakis. A.. Romeo. U.. 2013-10-24. Focal epithelial hyperplasia (Heck's disease). Annali di Stomatologia. 4. Suppl 2. 43. 1824-0852. 3860189. 24353818.
2. Book: James, William D. . Berger, Timothy G. . Andrews' Diseases of the Skin: clinical Dermatology . Saunders Elsevier . 2006 . 0-7216-2921-0 . etal.
3. Book: James. William D.. Berger. Timothy. Elston. Dirk. Andrews' Diseases of the Skin E-Book: Clinical Dermatology. 2015. Elsevier Health Sciences. 9780323319690. 408. en.
4. 10.1016/0030-4220(65)90192-1 . 14322615 . Focal epithelial hyperplasia: An unusual oral mucosal lesion found in Indian children . Oral Surgery, Oral Medicine, Oral Pathology . 20 . 2 . 201–12 . 1965 . Archard . Howell O . Heck . John W . Stanley . Harold R .
5. Book: Eversole. Lewis R.. Clinical Outline of Oral Pathology: Diagnosis and Treatment. 2011. PMPH-USA. 9781607950158. 285. 18 January 2018. en.