Fluproquazone Explained

Fluproquazone (trade name Tormosyl, RF 46-790) was a quinazolinone derivative with potent analgesic, antipyretic, and anti-inflammatory effects discovered by Sandoz.[1] [2] [3] [4] It was withdrawn during development due to liver toxicity.[5] [6]

Notes and References

  1. Haanaes HR, Benterud UJ, Skoglund LA . RF 46-790 versus paracetamol: effect on post-operative pain . International Journal of Clinical Pharmacology, Therapy, and Toxicology . 24 . 11 . 598–601 . November 1986 . 3491794 .
  2. Mohing W, Suckert R, Lataste X . Comparative study of fluproquazone in the management of post-operative pain . Arzneimittel-Forschung . 31 . 5a . 918–20 . 1981 . 6973986 .
  3. Wheatley D . Analgesic properties of fluproquazone . Rheumatology and Rehabilitation . 21 . 2 . 98–100 . May 1982 . 7043713 . 10.1093/rheumatology/21.2.98.
  4. Fankhauser S, Laube W, Marti HR, Schultheiss HR, Vögtlin J, von Graffenried B . Antipyretic activity of fluproquazone in man . Arzneimittel-Forschung . 31 . 5a . 934–5 . 1981 . 6973990 .
  5. Book: Lewis JH, Stine JG . Nonsteroidal Antiinflammatory Drugs and Leukotriene Receptor Antagonists . Drug-induced Liver Disease . third . Kaplowitz N, DeLeve LD . Elsevier Inc . 2013 . 9780123878175 .
  6. Book: Zimmerman HJ . Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the Liver . Lippincott Williams & Wilkins . 1999 . 9780781719520 .

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