Fluoromedroxyprogesterone acetate explained

Fluoromedroxyprogesterone acetate (FMPA, 9α-fluoromedroxyprogesterone acetate, or 9α-FMPA) is a synthetic steroid medication which was under development by Meiji Dairies Corporation in the 1990s and 2000s for the potential treatment of cancers but was never marketed.^{[1] [2] [3] [4] [5] [6] [7]} It is described as an antiangiogenic agent, with about two orders of magnitude greater potency for inhibition of angiogenesis than its parent compound medroxyprogesterone acetate. FMPA showed about the same affinities for the progesterone and glucocorticoid receptors as MPA. It reached the preclinical phase of research prior to the discontinuation of its development.

See also

• Anecortave acetate

External links

• Fluoromedroxyprogesterone acetate (FMPA) - AdisInsight

Notes and References

1. Web site: FMPA - AdisInsight.
2. Sugino E, Fujimori S, Hibino S, Choshi T, Ichihara Y, Sato Y, Yamaji T, Tsuboi H, Murata N, Uchida M, Shimamura M, Oikawa T . Synthesis of a new potent anti-angiogenic agent, 17 alpha-acetoxy-9 alpha-fluoro-6 alpha-methylprogesterone (9 alpha-fluoromedroxyprogesterone acetate [FMPA]) . Chem. Pharm. Bull. . 45 . 2 . 421–3 . February 1997 . 9118456 . 10.1002/chin.199737217 .
3. Kozutsumi D, Kawashima A, Sugimoto T, Kotohda Y, Fujimori S, Takami M, Kohno T, Oikawa T, Sugino E, Choshi T, Hibino S . Pharmacokinetics of 9alpha-fluoromedroxyprogesterone acetate in rats: comparison with medroxyprogesterone acetate . Biopharm Drug Dispos . 20 . 6 . 277–84 . September 1999 . 10701698 . 10.1002/(SICI)1099-081X(199909)20:6<277::AID-BDD186>3.0.CO;2-T . 8879650 .
4. Yamaji T, Tsuboi H, Murata N, Uchida M, Kohno T, Sugino E, Hibino S, Shimamura M, Oikawa T . Anti-angiogenic activity of a novel synthetic agent, 9alpha-fluoromedroxyprogesterone acetate . Cancer Lett. . 145 . 1–2 . 107–14 . October 1999 . 10530777 . 10.1016/S0304-3835(99)00239-6 .
5. Uchida M, Tsuboi H, Yamaji T, Murata N, Kohno T, Sugino E, Hibino S, Shimamura M, Oikawa T . Inhibition by 9alpha-fluoromedoroxyprogesterone acetate (FMPA) against mammary carcinoma induced by dimethylbenz[a]anthracene in rats and angiogenesis in the rabbit cornea - comparison with medroxyprogesterone acetate (MPA) . Cancer Lett. . 154 . 1 . 63–9 . June 2000 . 10799740 . 10.1016/S0304-3835(00)00375-X .
6. Murata N, Fujimori S, Ichihara Y, Sato Y, Yamaji T, Tsuboi H, Uchida M, Suzuki H, Yamada M, Oikawa T, Nemoto H, Nobuhiro J, Choshi T, Hibino S . Synthesis and anti-tumor activity of a fluorinated analog of medroxyprogesterone acetate (MPA), 9alpha-fluoromedroxyprogesterone acetate (FMPA) . Chem. Pharm. Bull. . 54 . 11 . 1567–70 . November 2006 . 17077554 . 10.1248/cpb.54.1567 . free .
7. Murata N, Yamaji T, Uchida M, Tsuboi H, Suzuki H, Yamada M, Oikawa T, Nobuhiro J, Choshi T, Hibino S . Suppression of laser-induced choroidal neovascularization by subconjunctival injection of 9alpha-fluoromedroxyprogesterone acetate (FMPA), an anti-angiogenic agent, in rats . Biol. Pharm. Bull. . 29 . 12 . 2410–4 . December 2006 . 17142973 . 10.1248/bpb.29.2410 . free .