Fluorolintane Explained

Fluorolintane (also known as 2-FPPP and 2-F-DPPy) is a dissociative anesthetic drug that has been sold online as a designer drug.^{[1] [2] [3] [4]}

Fluorolintane and related diarylethylamines are antagonists of the NMDA receptor^[5] and have been studied in vitro as potential treatments for neurotoxic injury,^[6] depression^[7] and as sympathomimetic.^[8]

See also

• AD-1211
• Alpha-D2PV
• Diphenidine
• Ephenidine
• Lanicemine
• Methoxphenidine (MXP)
• MT-45
• Prolintane
• Remacemide

Notes and References

1. Wallach J, Kavanagh PV, McLaughlin G, Morris N, Power JD, Elliott SP, Mercier MS, Lodge D, Morris H, Dempster NM, Brandt SD . 6 . Preparation and characterization of the 'research chemical' diphenidine, its pyrrolidine analogue, and their 2,2-diphenylethyl isomers . Drug Testing and Analysis . 7 . 5 . 358–367 . May 2015 . 25044512 . 10.1002/dta.1689 .
2. Web site: Analytical Report - Fluorolintane . Nacionalni forenzični laboratorij (NFL) . January 2016.
3. Wallach J, Colestock T, Agramunt J, Claydon MD, Dybek M, Filemban N, Chatha M, Halberstadt AL, Brandt SD, Lodge D, Bortolotto ZA, Adejare A . 6 . Pharmacological characterizations of the 'legal high' fluorolintane and isomers . European Journal of Pharmacology . 857 . 172427 . August 2019 . 31152702 . 6899220 . 10.1016/j.ejphar.2019.172427 .
4. Dybek M, Wallach J, Kavanagh PV, Colestock T, Filemban N, Dowling G, Westphal F, Elliott SP, Adejare A, Brandt SD . 6 . Syntheses and analytical characterizations of the research chemical 1-[1-(2-fluorophenyl)-2-phenylethyl]pyrrolidine (fluorolintane) and five of its isomers . Drug Testing and Analysis . 11 . 8 . 1144–1161 . August 2019 . 31033229 . 10.1002/dta.2608 . 139103681 .
5. Berger ML, Schweifer A, Rebernik P, Hammerschmidt F . NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds . Bioorganic & Medicinal Chemistry . 17 . 9 . 3456–62 . May 2009 . 19345586 . 10.1016/j.bmc.2009.03.025 .
6. Web site: Patent EP 0346791 B1 - 1,2-diarylethylamines for treatment of neurotoxic injury . 1994 . Gray NM, Cheng BK .
7. Web site: Patent US 3083139 A - Therapeutic 1-(1, 2-diphenylethyl) pyrrolidine for the management of depression . 1963 . Aspergren BD, Heinzelman RV .
8. Compounds Containing the Pyrrolidine Ring. Analogs of Sympathomimetic Amines . Heinzelman RV, Aspergren BD . Journal of the American Chemical Society . July 1953 . 75 . 14 . 3409–3413 . 10.1021/ja01110a033.