Fluoroiodomethane Explained
Fluoroiodomethane is the halomethane with the formula FCH2I. Also classified as a fluoroiodocarbon (FIC), it is a colorless liquid. It is a reagent for the introduction of the fluoromethyl (FCH2) group.
Synthesis and uses
It is prepared by fluorination of methylene iodide.[1]
Its isotopomer [<sup>18</sup>F]fluoroiodomethane is used for fluoromethylation of radiopharmaceuticals.
Additional reading
- Zheng L. . Berridge M. S. . January 2000 . Synthesis of [18F]fluoromethyl iodide, a synthetic precursor for fluoromethylation of radiopharmaceuticals . Applied Radiation and Isotopes . 52 . 1 . 55–61(7) . 10670923 . 10.1016/S0969-8043(99)00061-5 .
- Chin F. T. . Morse Ch. L. . Shetty H. U. . Pike V. W. . December 2005 . Automated radiosynthesis of [18F]SPA-RQ for imaging human brain NK1 receptors with PET . Journal of Labelled Compounds and Radiopharmaceuticals . 49 . 1 . 17–31(15) . 10.1002/jlcr.1016 . 2007-06-29 .
- Tedder, J. M. . Sloan, J. P. . Walton, J. C. . 1975 . Free Radical Addition to Olefins, Part XVII. Addition of Fluoroiodomethane to Fluoroethylenes. Journal of the Chemical Society . 1846–1850 .
Notes and References
- Encyclopedia: Fluoroiodomethane. Landelle. Gregory. Encyclopedia of Reagents for Organic Synthesis. Paquin. Jean-Francois. e-EROS Encyclopedia of Reagents for Organic Synthesis. 2011. 10.1002/047084289X.rn01273. 978-0471936237.