Fluorescein (medical use) explained

Drug Name:Fluorescein
Pronounce:[1]
Tradename:Fluorescite, AK-Fluor, BioGlo, others
Dailymedid:Fluorescein
Licence Us:Fluorescein
Routes Of Administration:Eye drops, intravenous, by mouth
Class:Diagnostic agent
Atc Prefix:S01
Atc Suffix:JA01
Legal Uk:POM
Legal Uk Comment:[2]
Legal Us:Rx-only
Legal Status:Rx-only
Index2 Label:sodium
Cas Number:2321-07-5
Cas Number2:518-47-8
Pubchem:16850
Drugbank:DB00693
Chemspiderid:15968
Unii:TPY09G7XIR
Unii2:93X55PE38X
Kegg:D01261
Kegg2:D02024
Chebi:31624
Chembl:1057
Pdb Ligand:FLU
Iupac Name:3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
C:20
H:12
O:5
Smiles:C1=CC=C2C(=C1)C(=O)OC23C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O
Stdinchi:1S/C20H12O5/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20/h1-10,21-22H
Stdinchikey:GNBHRKFJIUUOQI-UHFFFAOYSA-N

Fluorescein is used to help in the diagnosis of a number of eye problems. When applied as a drop or within a strip of paper to the surface of the eye it is used to help detect eye injuries such as foreign bodies and corneal abrasions.[3] [4] When given by mouth or injection into a vein it is used to help evaluate the blood vessels in the back of the eye during fluorescein angiography.[5]

When applied to the surface of the eye, side effects may include a brief period of blurry vision and discoloration of contact lenses of the soft type.[6] When used by mouth or injection, side effects may include headache, nausea, and a change to the color of the skin for a brief period of time. Allergic reactions may rarely occur. Fluorescein is a dye which is taken up by damaged cornea such that the area appears green under cobalt blue light.[7] There is also a version that comes premixed with lidocaine.[3] [8]

Fluorescein was first made in 1871.[9] It is on the World Health Organization's List of Essential Medicines.[10]

Brand names

It is also sold as a combination drug with oxybuprocaine under the brand name Altafluor Benox.[11] [12]

Other animals

It is also sometimes administered to pets in multi-pet environments to determine which pet needs behavioral modification.

External links

Notes and References

  1. Web site: Fluorescein | Definition of Fluorescein by Oxford Dictionary on Lexico.com also meaning of Fluorescein. https://web.archive.org/web/20210114123453/https://www.lexico.com/definition/fluorescein. dead. 14 January 2021. Lexico Dictionaries | English.
  2. Web site: Fluorescein sodium 100 mg/ml, solution for injection - Summary of Product Characteristics (SmPC) . (emc) . 16 January 2018 . 11 March 2020.
  3. Book: British national formulary : BNF 69. 2015. British Medical Association. 9780857111562. 769, 772. 69.
  4. Book: Hamilton R . Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. 2015. Jones & Bartlett Learning. 9781284057560. 416.
  5. Web site: Anatera 100mg/ml solution for injection - Summary of Product Characteristics (SmPC) . (emc) . 10 February 2020 . 11 March 2020.
  6. Book: WHO Model Formulary 2008 . 2009 . 9789241547659 . ((World Health Organization)) . Stuart MC, Kouimtzi M, Hill SR . 10665/44053 . World Health Organization . World Health Organization . free . 314 .
  7. Duvall B, Kershner RM . Ophthalmic medications and pharmacology . Journal of Ophthalmic Nursing & Technology . 17 . 4 . 151–158 . 2006 . 9883136 . live . SLACK Incorporated . 9781556427503 . https://web.archive.org/web/20170118050803/https://books.google.ca/books?id=YsYi6dzIKKUC&pg=PA29 . 2017-01-18 .
  8. Web site: Minims Lidocaine & Fluorescein Summary of Product Characteristics (SmPC) - (emc) . (emc) . 23 October 2017 . 11 March 2020.
  9. Book: Bartlett JD, Jaanus SD . Clinical Ocular Pharmacology. 2008. Elsevier Health Sciences. 978-0750675765. 283. en. live. https://web.archive.org/web/20170118050759/https://books.google.ca/books?id=Eybg7fbs65MC&pg=PA283. 2017-01-18.
  10. Book: ((World Health Organization)) . World Health Organization model list of essential medicines: 21st list 2019 . 2019 . 10665/325771 . World Health Organization . World Health Organization . Geneva . WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO . free .
  11. Web site: Drug Approval Package: Altafluor Benox (fluorescein sodium and benoxinate hydrochloride ophthalmic solution) . U.S. Food and Drug Administration (FDA) . 9 April 2018 . 11 March 2020.
  12. Web site: Altafluor- fluorescein sodium and benoxinate hydrochloride solution . DailyMed . U.S. National Library of Medicine . 4 December 2017 . 10 March 2020.

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