Flugestone acetate explained

Flugestone acetate (FGA), sold under the brand name Cronolone among others, is a progestin medication which is used in veterinary medicine.^{[1] [2] [3] [4] [5] [6]}

Uses

Veterinary

FGA is used as an intravaginal sponge preparation to synchronize estrus in ewes and goats.

Chemistry

See also: List of progestogens, Progestogen ester and List of progestogen esters.

FGA, also known as 17α-acetoxy-9α-fluoro-11β-hydroxyprogesterone or as 17α-acetoxy-9α-fluoro-11β-hydroxypregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone and 17α-hydroxyprogesterone. It is the C17α acetate ester of flugestone.

History

FGA was developed and marketed by G.D. Searle & Company in the 1960s.^{[7] [8]}

Society and culture

Generic names

Flugestone acetate is the generic name of the drug and its and, while flurogestone acetate is its .^[9] Flugestone is the and of the unesterified free alcohol form. FGA is also known by its developmental code names NSC-65411 and SC-9880.

Brand names

FGA is or has been marketed under the brand names Chronogest, Chrono-Gest, Crono-Gest, Cronolone, Gyncro-Mate, Ova-Gest, Ovakron, Synchro-Mate, Syncro Part, and Syncropart.

Availability

FGA is marketed for veterinary use in Australia, France, Ireland, Israel, Italy, the Netherlands, South Africa, and the United Kingdom.

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 559.
2. Book: Morton IK, Hall JM . Concise Dictionary of Pharmacological Agents: Properties and Synonyms. 31 October 1999. Springer Science & Business Media. 978-0-7514-0499-9. 122–.
3. Book: Index Nominum 2000: International Drug Directory. January 2000. Taylor & Francis. 978-3-88763-075-1. 451–.
4. Book: Office of the Federal Register (US) . Code of Federal Regulations Title 21: Food and Drug Administration: Parts 500-599, Revised April 1, 2012. 29 May 2012. Government Printing Office. 978-0-16-090718-0. 359–.
5. Book: Youngquist RS, Threlfall WR . Current Therapy in Large Animal Theriogenology. 23 November 2006. Elsevier Health Sciences. 1-4377-1340-8. 2640–.
6. Book: Studdert VP, Gay CC, Blood DC . Saunders Comprehensive Veterinary Dictionary. 9 December 2011. Elsevier Health Sciences. 978-0-7020-4744-2. 2673–.
7. Book: Animal Husbandry Research: Reports on Agricultural Industry. 1967. 60.
8. Book: Dairy Science Handbook. 1971. Agriservices Foundation. 10.
9. Web site: Flugestone . Drugs.com .