Fluclotizolam Explained

Fluclotizolam is a thienotriazolodiazepine derivative which was first synthesised in 1979,^[1] but was never marketed. It has subsequently been sold as a designer drug, first being definitively identified in 2017.^{[2] [3] [4] [5] [6] [7]}

See also

• Brotizolam
• Clotizolam
• Deschloroclotizolam
• Etizolam
• Flualprazolam
• Fluadinazolam
• Flubrotizolam
• Fluetizolam
• Ro09-9212

Notes and References

1. Hellerbach J, Zeller P, Binder D, Hromatka O . Hoffmann La Roche Inc . 22 May 1979 . Thienotriazolodiazepine derivatives. . US . 4155913 .
2. Zawilska JB, Wojcieszak J . An expanding world of new psychoactive substances-designer benzodiazepines . Neurotoxicology . 73 . 8–16 . July 2019 . 30802466 . 10.1016/j.neuro.2019.02.015 . 73461430 .
3. Book: Moosmann B, Auwärter V . 2018 . Designer Benzodiazepines: Another Class of New Psychoactive Substances. . Maurer H, Brandt S . New Psychoactive Substances . Handbook of Experimental Pharmacology . 252 . 383–410 . 10.1007/164_2018_154 . 30367253 . 978-3-030-10560-0 .
4. Chetraru E, Ameline A, Gheddar L, Raul JS, Kintz P . Les designer benzodiazepines: qu'en sait-on aujourd'hui?. . Toxicologie Analytique et Clinique . February 2018 . 30 . 1 . 5–18 . 10.1016/j.toxac.2017.12.001 .
5. Orsolini L, Corkery JM, Chiappini S, Guirguis A, Vento A, De Berardis D, Papanti D, Schifano F . 6 . 'New/Designer Benzodiazepines': An Analysis of the Literature and Psychonauts' Trip Reports . Current Neuropharmacology . 18 . 9 . 809–837 . 2020 . 31933443 . 7569319 . 10.2174/1570159X18666200110121333 .
6. Catalani V, Botha M, Corkery JM, Guirguis A, Vento A, Scherbaum N, Schifano F . The Psychonauts' Benzodiazepines; Quantitative Structure-Activity Relationship (QSAR) Analysis and Docking Prediction of Their Biological Activity . Pharmaceuticals . 14 . 8 . 720 . July 2021 . 34451817 . 8398354 . 10.3390/ph14080720 . free .
7. Catalani V, Floresta G, Botha M, Corkery JM, Guirguis A, Vento A, Abbate V, Schifano F . 6 . In silico studies on recreational drugs: 3D quantitative structure activity relationship prediction of classified and de novo designer benzodiazepines . Chemical Biology & Drug Design . 101 . 1 . 40–51 . January 2023 . 35838189 . 10.1111/cbdd.14119 . free . 250559695 . 2299/25749 .