Flubromazepam Explained

Flubromazepam is a benzodiazepine derivative which was first synthesized in 1960,[1] but was never marketed and did not receive any further attention or study until late 2012 when it appeared on the grey market as a novel designer drug.[2] [3] [4] [5] [6] [7] [8]

It is a structural analog of phenazepam in which the chlorine atom has been replaced by a fluorine atom.

An alternate isomer, 5-(2-bromophenyl)-7-fluoro-1,3-dihydro-2H-1,4-benzodiazepin-2-one or "iso-flubromazepam",[9] may have been sold under the same name.[2]

Legal status

United Kingdom

In the UK, flubromazepam has been classified as a Class C drug by the May 2017 amendment to The Misuse of Drugs Act 1971 along with several other designer benzodiazepine drugs.[10]

United States

Flubromazepam, clonazolam, and flubromazolam are Schedule I controlled substances under Virginia State Law.[11]

See also

Notes and References

  1. US . 3136815 . Amino substituted benzophenone oximes and derivatives thereof.
  2. Moosmann B, Huppertz LM, Hutter M, Buchwald A, Ferlaino S, Auwärter V . Detection and identification of the designer benzodiazepine flubromazepam and preliminary data on its metabolism and pharmacokinetics . Journal of Mass Spectrometry . 48 . 11 . 1150–9 . November 2013 . 24259203 . 10.1002/jms.3279 . 2013JMSp...48.1150M .
  3. Web site: Characterization of the designer benzodiazepines pyrazolam and flubromazepam and study on their detectability in human serum and urine samples . Institute of Forensic Medicine, Forensic Toxicology, University Medical Center Freiburg, Freiburg, Germany . Moosmann B, Hutter M, Huppertz LM, Auwärter V .
  4. O'Connor LC, Torrance HJ, McKeown DA . ELISA Detection of Phenazepam, Etizolam, Pyrazolam, Flubromazepam, Diclazepam and Delorazepam in Blood Using Immunalysis® Benzodiazepine Kit . Journal of Analytical Toxicology . 40 . 2 . 159–61 . March 2016 . 26518230 . 10.1093/jat/bkv122 . free .
  5. Web site: Flubromazepam . 12 November 2023 . New Synthetic Drugs Database.
  6. Pettersson Bergstrand M, Helander A, Hansson T, Beck O . Detectability of designer benzodiazepines in CEDIA, EMIT II Plus, HEIA, and KIMS II immunochemical screening assays . Drug Testing and Analysis . 9 . 4 . 640–645 . April 2017 . 27366870 . 10.1002/dta.2003 .
  7. Høiseth G, Tuv SS, Karinen R . Blood concentrations of new designer benzodiazepines in forensic cases . Forensic Science International . 268 . 35–38 . November 2016 . 27685473 . 10.1016/j.forsciint.2016.09.006 .
  8. Manchester KR, Maskell PD, Waters L . a and plasma protein binding values for benzodiazepines appearing as new psychoactive substances . Drug Testing and Analysis . March 2018 . 29582576 . 10.1002/dta.2387 . 31098917 .
  9. Baumeister D, Tojo LM, Tracy DK . Legal highs: staying on top of the flood of novel psychoactive substances . Therapeutic Advances in Psychopharmacology . 5 . 2 . 97–132 . April 2015 . 26240749 . 4521440 . 10.1177/2045125314559539 .
  10. Web site: The Misuse of Drugs Act 1971 (Amendment) Order 2017 . Legislation.gov.uk .
  11. Web site: Administrative Code 18VAC110-20-322. Placement of Chemicals in Schedule I. . Virginia Law .

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