Fluacizine Explained

Fluacizine, sold under the brand name Phtorazisin, is a tricyclic antidepressant (TCA) of the phenothiazine group which is or was marketed in Russia.^{[1] [2] [3]} Unlike other phenothiazines, fluacizine is not an antipsychotic, and can actually reverse catalepsy and extrapyramidal symptoms induced by antidopaminergic agents like antipsychotics, reserpine, and tetrabenazine as well as potentiate amphetamine-induced stereotypy. It is known to act as a norepinephrine reuptake inhibitor, antihistamine, and anticholinergic.^{[4] [5] [6] [7]} The drug was developed in the 1960s and was marketed in the 1970s. It is the trifluoromethyl analogue of chloracizine.

See also

• Pipofezine

Notes and References

1. Book: J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 555–.
2. Book: O'Neil, Maryadele J. . The Merck index: an encyclopedia of chemicals, drugs, and biologicals . Merck Research Laboratories . Rahway, NJ . 2001 . 0-911910-13-1 . registration .
3. Book: V. V. Zakusov. Pharmacology of Central Synapses. 22 October 2013. Elsevier. 978-1-4831-4673-7. 190–.
4. Arefolov VA, Panasyuk LV, Raevskii KS, Kostyukov VI . Effect of fluacizine on the uptake of exogenous noradrenalin by the isolated rat vas deferens . Bull. Exp. Biol. Med. . 77 . 3 . 295–7 . 1974 . 4153328 . 10.1007/BF00802484. 13188296 .
5. Arefolov VA, Panasyuk LV . Effect of fluacizine on the uptake of exogenous noradrenalin . Bull. Exp. Biol. Med. . 77 . 5 . 520–3 . 1974 . 4441683 . 10.1007/BF00797411. 27205700 .
6. Arefolov VA, Panasiuk LV, Firsov VK . [Neuromediator content in the synaptic vesicles of rat adrenergic nerves in some pharmacological actions] . ru . Farmakol Toksikol . 38 . 3 . 285–9 . 1975 . 6305 .
7. Book: Annual Reports in Medicinal Chemistry. 27 October 1972. Academic Press. 978-0-08-058351-8. 19–.