| State: | FL |
| Type: | SR |
| Route: | 405 |
| Map Custom: | yes |
| Map Notes: | SR 405 in red, CR 405 in blue |
| Maint: | FDOT |
| Length Mi: | 9.828 |
| Length Round: | 3 |
| Direction A: | East |
| Terminus A: | in Titusville |
| Junction: | in Titusville |
| Direction B: | North |
| Terminus B: | in Titusville |
| Counties: | Brevard |
| Previous Type: | SR |
| Previous Route: | 404 |
| Next Type: | SR |
| Next Route: | 406 |
State Road 405 (SR 405) is a state highway making a sweeping arc in Titusville, Florida, and, via the nearby NASA Parkway, providing a major access route for the Kennedy Space Center on nearby Merritt Island. The northern terminus of SR 405 is an intersection with North Washington Avenue (U.S. 1) in downtown Titusville; the eastern terminus is at a cloverleaf interchange with U.S. 1 near the American Police Hall of Fame & Museum. It is locally known as South Street and Columbia Boulevard.
South of Cheney Highway (SR 50), SR 405 is signed east - west and is named Columbia Boulevard. North of SR 50, SR 405 is signed north - south and is named South Street. It parallels Interstate 95 for 2.2miles - from Cheney Highway to Willis Drive - before veering off to the northeast towards downtown Titusville.
In addition, SR 405 passes by Space Coast Regional Airport (formerly Ti-Co (Titusville-Cocoa) Airport) and Enchanted Forest Park.