| State: | FL |
| Type: | SR |
| Route: | 222 |
| Alternate Name: | North 39th Avenue |
| Map Custom: | yes |
| Map Notes: | SR 222 highlighted in red |
| Maint: | FDOT |
| Length Mi: | 14.174 |
| Length Round: | 3 |
| Direction A: | West |
| Terminus A: | near Gainesville |
| Junction: | in Gainesville in Gainesville |
| Direction B: | East |
| Terminus B: | in Gainesville |
| Previous Type: | US |
| Previous Route: | 221 |
| Next Type: | SR |
| Next Route: | 223 |
State Road 222 (SR 222) is a 14.174-mile-long state road that serves northern Gainesville. The western terminus is at a diamond interchange with I-75 at exit 390, and the eastern terminus is at a fork at SR 26 just east of Gainesville.
It is 4 lanes wide, but narrows to 2 lanes east of Airport Access Road, where it runs along the northwestern edges of the Newnans Lake State Forest[1] [2] followed by the Newnans Lake Conservation Area.[3] At its western terminus, NW 39th Avenue continues west as two lane County Road 222 towards CR 241, a long county road.