| Florencia Ponce de Leon | |
| Birth Date: | 26 February 1992 |
| Birth Place: | Buenos Aires, Argentina |
| Height: | 1.79 m |
| Position: | Left back |
| Currentclub: | Liberbank Gijón |
| Clubnumber: | 15 |
| Years1: | 2013–2018 |
| Clubs1: | Club Oeste |
| Years2: | 2018– |
| Clubs2: | Liberbank Gijón |
| Nationalteam1: | Argentina |
| Nationalcaps1: | 41 |
| Nationalgoals1: | 75 |
Florencia Ponce de Leon (born 26 February 1992) is an Argentine handball player for the Liberbank Gijón and the Argentine national team.[1]
She competed at the 2015 World Women's Handball Championship in Denmark.[2]