| Florence MacDonald | |
| Birth Date: | October 27, 1909 |
| Birth Place: | Sydney, Nova Scotia, Canada |
| Death Date: | May 6, 2008 (aged 98) |
| Death Place: | South Boston, Massachusetts, United States |
| Sport: | Running |
| Club: | Boston Swimming Association |
| Olympics: | 1928 |
| Show-Medals: | yes |
Florence E. MacDonald (October 28, 1909 – May 6, 2008) was an American middle-distance runner. She competed at the 1928 Olympics in the 800 m event and finished in sixth place, setting a new national record at 2:22.6.
MacDonald was born to Angus R. and Mary (Currie) MacDonald and had two sisters, Christina E. MacDonald and Margaret Janowicz. She married Peter Campbell and gave birth to a daughter, June Marie Russo, and a son, John Scott Campbell. For 25 years she worked as a nurse at a school of medicine.
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