| Official Name: | Florence, Missouri |
| Settlement Type: | Unincorporated community |
| Mapsize: | 250px |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Missouri |
| Subdivision Type2: | County |
| Subdivision Name2: | Morgan |
| Unit Pref: | Imperial |
| Population As Of: | 2010 |
| Population Est: | 530 |
| Pop Est As Of: | 2011 |
| Population Total: | 494 |
| Timezone: | Central (CST) |
| Utc Offset: | -6 |
| Timezone Dst: | CDT |
| Utc Offset Dst: | -5 |
| Elevation Ft: | 945 |
| Coordinates: | 38.5889°N -92.9792°W |
| Postal Code Type: | ZIP code |
| Postal Code: | 65329 |
| Area Code: | 660 |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 729740 |
Florence is an unincorporated community in Morgan County, Missouri, United States. It is located eight miles south of U.S. Route 50 on Missouri Route 135.
A post office called Florence has been in operation since 1839.[1] Early variant names were "Williamsville" and "Jonesboro".[2]