Flestolol Explained

Flestolol is a short-acting beta adrenergic receptor antagonist.[1]

Synthesis

Acylation of acid chloride 2-Fluorobenzoyl chloride [393-52-2] (1) with glycidol (2) produces the ester 2,3-Epoxypropyl 2-Fluorobenzoate [85515-51-1] (3). Reaction of that intermediate with amine (2-Amino-2-methyl-propyl)-urea [87484-83-1] (4) obtained by reaction of 1,1-dimethylethylenediamine with urea, gives flestolol (5).

Notes and References

  1. 8235065. 1993. Quon. CY. Stampfli. HF. Biochemical characterization of flestolol esterase. 81. 3. 309–22. Research communications in chemical pathology and pharmacology.