Flavanonol Explained

The flavanonols (with two "o"s a.k.a. 3-hydroxyflavanone or 2,3-dihydroflavonol) are a class of flavonoids that use the 3-hydroxy-2,3-dihydro-2-phenylchromen-4-one (IUPAC name) backbone.

Some examples include:

• Taxifolin (or Dihydroquercetin)
• Aromadedrin (or Dihydrokaempferol)
• Engeletin (or Dihydrokaempferol-3-rhamnoside)

Metabolism

• Flavanone 3-dioxygenase
• Flavonol synthase
• Dihydroflavonol 4-reductase

Glycosides

Glycosides (chrysandroside A and chrysandroside B) can be found in the roots of Gordonia chrysandra.^[1] Xeractinol, a dihydroflavonol C-glucoside, can be isolated from the leaves of Paepalanthus argenteus var. argenteus.^[2]

Dihydro-flavonol glycosides (astilbin, neoastilbin, isoastilbin, neoisoastilbin, (2R, 3R)-taxifolin-3'-O-β-D-pyranoglucoside) have been identified in the rhizome of Smilax glabra.^[3]

Notes and References

1. Kun Wanga . Jing Zhi Yanga . Li Zuoa . Dong Ming Zhang . Two new flavanonol glycosides from Gordonia chrysandra . Chinese Chemical Letters . 19 . 1 . 61–4 . January 2008 . 10.1016/j.cclet.2007.10.033 .
2. Anne Lígia Dokkedal . Francisco Lavarda . Lourdes Campaner dos Santos . Wagner Vilegas . Xeractinol – a new flavanonol C-glucoside from Paepalanthus argenteus var. argenteus (Bongard) Hensold (Eriocaulaceae) . J. Braz. Chem. Soc. . 18 . 2 . 437–439. March–April 2007 . 10.1590/S0103-50532007000200029 . free . 11449/36324 . free .
3. Yuan JZ, Dou DQ, Chen YJ . [Studies on dihydroflavonol glycosides from rhizome of Smilax glabra] . Chinese . Zhongguo Zhong Yao Za Zhi . 29 . 9 . 867–70 . September 2004 . 15575206 . etal.