| Post: | First Lady |
| Body: | Missouri |
| Insignia: | Flag of Missouri.svg |
| Insigniasize: | 100 |
| Incumbent: | Teresa Parson |
| Incumbentsince: | June 1, 2018 |
| Formation: | 1820 |
| Inaugural: | Marguerite de Reilhe |
| Website: | Missouri's First Lady |
First Lady of Missouri is the honorary title attributed to the wife of the governor of Missouri. To date there have been no female governors of Missouri, and all the governors' spouses have been women. The first governor of Missouri was elected and took office in 1820, the year before Missouri was admitted to the Union as the 24th state.
| Image | Name | Took office | Left office | Governor of Missouri |
|---|---|---|---|---|
| Marguerite Suzanne de Reilhe | 1820 | 1824 | Alexander McNair | |
| Nancy Opie Ball | 1824 | 1825 | Frederick Bates | |
| none (Williams never married) | 1825 | 1826 | Abraham J. Williams | |
| none (Miller never married) | 1826 | 1832 | John Miller | |
| Emily Willis "Pamela" Haley | 1832 | 1836 | Daniel Dunklin | |
| Panthea Grant Boone | 1836 | 1840 | Lilburn Boggs | |
| Eliza Ann Young | 1840 | 1844 | Thomas Reynolds | |
| Lavinia Sappington | 1844 | 1844 | Meredith Miles Marmaduke | |
| none (Edwards not married) | 1844 | 1848 | John Cummins Edwards | |
| Nancy Harris Roberts | 1848 | 1853 | Austin Augustus King | |
| Martha Head | 1853 | 1857 | Sterling Price | |
| Elizabeth Skinner | 1857 | 1857 | Trusten Polk | |
| Ursula Oldham | 1857 | 1857 | Hancock Lee Jackson | |
| none (Stewart never married) | 1857 | 1861 | Robert Marcellus Stewart | |
| Elza Sappington | 1861 | 1861 | Claiborne Fox Jackson | |
| Caroline J. Coalter | 1861 | 1864 | Hamilton Rowan Gamble | |
| unknown[1] | 1864 | 1865 | Willard Preble Hall | |
| Mary Clara Honey | 1865 | 1869 | Thomas Clement Fletcher | |
| Mary Catherine Johnson | 1869 | 1871 | Joseph W. McClurg | |
| Mary Ginn | 1871 | 1873 | Benjamin Gratz Brown | |
| Virginia Juliet Lard | 1872 | 1875 | Silas Woodson | |
| Mary Barr Jenkins | 1875 | 1877 | Charles Henry Hardin | |
| Mary Whitney | 1877 | 1881 | John S. Phelps | |
| Caroline Wheeler "Carrie" Jackson | 1881 | 1885 | Thomas Theodore Crittenden | |
| none (Marmaduke never married) | 1885 | 1887 | John S. Marmaduke | |
| Mattie McFadden | 1887 | 1889 | Albert P. Morehouse | |
| Jane Perry | 1889 | 1893 | David R. Francis | |
| Sarah Louise Winston | 1893 | 1897 | William J. Stone | |
| Margaret Nelson | 1897 | 1901 | Lon Vest Stephens | |
| Mary Elizabeth Bird | 1901 | 1903 | Alexander Monroe Dockery | |
| none (Dockery was widowed) | 1903 | 1905 | ||
| Gertrude Glass | 1905 | 1909 | Joseph W. Folk | |
| Agnes Lee | 1909 | 1913 | Herbert S. Hadley | |
| Elizabeth Myers | 1913 | 1917 | Elliot Woolfolk Major | |
| Jeannette Vosburgh | 1917 | 1921 | Frederick D. Gardner | |
| Hortense Cullers | 1921 | 1925 | Arthur M. Hyde | |
| Nelle Rose Tuckley | 1925 | 1929 | Sam Aaron Baker | |
| Fannie Alice Delano | 1929 | 1933 | Henry S. Caulfield | |
| Eleanora Gabbert | 1933 | 1937 | Guy Brasfield Park | |
| Katherine Lemoine Perkins | 1937 | 1941 | Lloyd C. Stark | |
| Hilda Hays | 1941 | 1945 | Forrest C. Donnell | |
| Juanita McFadden | 1945 | 1949 | Phil M. Donnelly | |
| Mildred Williams | 1949 | 1953 | Forrest Smith | |
| Juanita McFadden | 1953 | 1957 | Phil M. Donnelly | |
| Emilie Chorn | 1957 | 1961 | James T. Blair Jr. | |
| Geraldine Hall | 1961 | 1965 | John M. Dalton | |
| Betty Sue Cooper | 1965 | 1973 | Warren E. Hearnes | |
| Carolyn Reid | 1973 | 1977 | Kit Bond | |
| Theresa Ferkenhoff | 1977 | 1981 | Joseph P. Teasdale | |
| Carolyn Reid | 1981 | 1985 | Kit Bond | |
| Janet E. Ashcroft | 1985 | 1993 | John Ashcroft | |
| Jean Carpenter | 1993 | 2001 | Mel Carnahan | |
| Pat Wilson | 2000 | 2001 | Roger B. Wilson | |
| Lori Hauser | 2001 | 2005 | Bob Holden | |
| Melanie Anderson | 2005 | 2009 | Matt Blunt | |
| Georganne Wheeler | 2009 | 2017 | Jay Nixon | |
| Sheena Elise Chestnut | 2017 | 2018 | Eric Greitens | |
| Teresa Parson | 2018 | serving | Mike Parson | |