| First Presbyterian Church | |
| Nrhp Type: | cp |
| Nocat: | yes |
| Partof: | Boneyfiddle Commercial District |
| Partof Refnum: | 79001938 |
| Location: | 221 Court St., Portsmouth, Ohio |
| Coordinates: | 38.7319°N -83.0011°W |
| Built: | 1849 |
| Architecture: | Greek Revival |
| Added: | November 28, 1973 |
| Area: | Less than |
| Refnum: | 73001532 |
First Presbyterian Church is a historic church at 221 Court Street in Portsmouth, Ohio.
The Greek Revival church building was constructed in 1849. It was added to the National Register of Historic Places in 1973.