| Post: | First Lady |
| Body: | Uzbekistan |
| Insignia: | Emblem of Uzbekistan.svg |
| Incumbent: | Ziroat Mirziyoyeva |
| Incumbentsince: | December 14, 2016 |
| Formation: | September 1, 1991 |
| Inaugural: | Tatyana Karimova |
| Native Name: | Oʻzbekistonning birinchi xonimlari |
First Lady of Uzbekistan is the title attributed to the wife of the president of Uzbekistan. The current first lady of Uzbekistan is Ziroat Mirziyoyeva, wife of President Shavkat Mirziyoyev.
| Image | Name | Term in office | President | Note | ||||
|---|---|---|---|---|---|---|---|---|
| Term start | Term end | Time in office | ||||||
| 1 | Tatyana Karimova | 1 September 1991 | 2 September 2016 | Islam Karimov | ||||
| Vacant Nigmatilla Yuldashev never married | 2 September 2016 | 14 December 2016 | Nigmatilla Yuldashev | |||||
| 2 | Ziroat Mirziyoyeva | 14 December 2016 | Incumbent | Shavkat Mirziyoyev | ||||