| Post: | First Lady |
| Body: | Guyana |
| Insignia: | Flag of Guyana.svg |
| Insigniasize: | 100px |
| Incumbent: | Arya Ali |
| Incumbentsince: | August 2, 2020 |
| Residence: | State House, Georgetown, Guyana |
| Formation: | March 17, 1970 |
| Inaugural: | Doreen Chung |
First Lady of Guyana is the title held by the wife of the president of Guyana. The current first lady of Guyana is Arya Ali, wife of President Irfaan Ali, who has served in the position since August 2020.
| Name | Term Begins | Term Ends | President of Guyana | Notes |
|---|---|---|---|---|
| Doreen Chung[1] | 17 March 1970 | 6 October 1980 | Arthur Chung | |
| Viola Burnham ♦[2] | 6 October 1980 | 6 August 1985 | Forbes Burnham | |
| Joyce Hoyte[3] | 6 August 1985 | 9 October 1992 | Desmond Hoyte | |
| Janet Jagan | 9 October 1992 | 6 March 1997 | Cheddi Jagan | Janet Jagan served as the 6th President of Guyana from 1997 to 1999 |
| Yvonne Hinds | 6 March 1997 | 19 December 1997 | Sam Hinds | |
| Widowed | 19 December 1997 | 11 August 1999 | Janet Jagan | |
| 11 August 1999 | 2007 (Divorced)[4] [5] | Bharrat Jagdeo | ||
| Office vacant | 2007 | 3 December 2011 | Bharrat Jagdeo | |
| Deolatchmee Ramotar | 3 December 2011 | 16 May 2015 | Donald Ramotar | |
| Sandra Granger | 16 May 2015 | 2 August 2020 | David Granger | |
| Arya Ali | 2 August 2020 | Present | Irfaan Ali | |
♦ Viola Burnham later served as Vice President of Guyana and deputy prime minister from 1985 to 1991.[2]