| Post: | First Lady |
| Body: | Cameroon |
| Insignia: | Flag of Cameroon.svg |
| Insigniasize: | 150px |
| Incumbent: | Chantal Biya |
| Incumbentsince: | 23 April 1994 |
| Formation: | 1 January 1960 |
| Inaugural: | Germaine Ahidjo |
First Lady of the Republic of Cameroon[1] refers to the wife of the president of Cameroon. Chantal Biya, the second wife of President Paul Biya, became First Lady upon her marriage to Biya on April 23, 1994.
| Portrait | Name | Term Begins | Term Ends | Time in Office | President or Head of State | Notes | |
|---|---|---|---|---|---|---|---|
| 1 | Germaine Ahidjo (1932–2021) | 1 January 1960 | 6 November 1982 | Ahmadou Ahidjo | Inaugural First Lady of Cameroon | ||
| 2 | Jeanne-Irène Biya (1935–1992) | 6 November 1982 | 29 July 1992 | Paul Biya | First Lady Jeanne-Irène Biya died in Yaoundé on 29 July 1992 | ||
| Office Vacant | 29 July 1992 | 23 April 1994 | Biya was a widower following the death of Jeanne-Irène Biya | ||||
| 3 | Chantal Biya (1969–) | 23 April 1994 (Marriage) | Present | Chantal Biya married President Biya on 23 April 1994. | |||