| Post: | First Lady |
| Body: | Afghanistan |
| Insignia: | Standard of the President of Afghanistan.svg |
| Insigniasize: | 100px |
| Insigniacaption: | First Lady's Standard |
| Flag: | Flag of Afghanistan (2013–2021).svg |
| Flagsize: | 125px |
| Flagcaption: | Flag of the Islamic Republic of Afghanistan |
| Last: | Rula Ghani |
| Residence: | Presidential Citadel, Kabul, Afghanistan |
| Termlength: | Concurrent with the president's term (unless a divorce or death takes place) |
| Formation: | 17 July 1973 |
| First: | Zamina Begum |
| Abolished: | 15 August 2021 |
| Status: | Presidency abolished |
First Lady of Afghanistan was the title attributed to the wife of the president of Afghanistan. Rula Ghani, wife of former President Ashraf Ghani, was the last and most recent first lady of Afghanistan from 2014 to 2021.
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| Nº | Image | First Lady | Birth | Marriage | President | Tenure began | Tenure ended | Age at tenure start | Death | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Zamina Begum | 1917 | September 1934 |  Mohammed Daoud Khan | 17 July 1973 | 28 April 1978 | 55–56 | 1978 | ||
| 2 | Fatana Najib | 1953 | Mohammad Najibullah | 30 September 1987 | 16 April 1992 | - | ||||
| 3 | Zeenat Karzai[1] [2] | 1970 | 1999 | Hamid Karzai | 22 December 2001 | 29 September 2014 | 31 | - | ||
| 4 | Rula Saadah | 1948 | 1975 | Ashraf Ghani | 29 September 2014 | 15 August 2021 | 64 | - |