The First Government of the Lao People's Democratic Republic was established on 2 December 1975.
| Ministry | Minister | Took office | Left office | |
|---|---|---|---|---|
| Prime Minister | Kaysone Phomvihane | 2 December 1975 | 1 June 1989 | |
| First Deputy Prime Minister | Nouhak Phoumsavan | January 1982 | 1 June 1989 | |
| Deputy Prime Minister | Nouhak Phoumsavan | 2 December 1975 | January 1982 | |
| Deputy Prime Minister | Phoumi Vongvichit | 2 December 1975 | 1 June 1989 | |
| Deputy Prime Minister and Minister of Foreign Affairs | Phoun Sipraseuth | 2 December 1975 | 1 June 1989 | |
| Deputy Prime Minister and Minister of Defense | Khamtay Siphandon | 2 December 1975 | 1 June 1989 | |
| Deputy Prime Minister | Sali Vongkhamxao | 1982 | 1 June 1989 | |
| Minister of Education | Phoumi Vongvichit | 2 December 1975 | January 1982 | |
| Bountiam Pitsami | January 1982 | 1988 | ||
| Samane Vignaket | 1988 | 1 June 1989 | ||
| Minister to the Office of the Prime Minister | Sali Vongkhamxao | 2 December 1975 | 1982 | |
| Minister to the Office of the Prime Minister | Sisavath Keobounphanh | 2 December 1975 | 1 June 1989 | |
| Minister to the Office of the Prime Minister | Chanmi Douangboutdi | 2 December 1975 | 1 June 1989 | |
| Minister to the Office of the Prime Minister | Maichantan Sengmani | 2 December 1975 | 1 June 1989 | |
| Minister of Finance | Nouhak Phoumsavan | 2 December 1975 | January 1982 | |
| Yao Phonvantha | January 1982 | 1 June 1989 | ||
| Minister of Interior, Veterans, and Social Affairs | Somseun Khamphithoun | 2 December 1975 | ? | |
| Minister of Welfare and Social Affairs | ? | ? | ? | |
| Minister of Interior | Asang Laoli | 1988 | 1 June 1989 | |
| Minister of Information, Propaganda, Culture, and Tourism | Sisana Sisane | 2 December 1975 | 1 June 1989 | |
| Minister of Communications and Public Works | Sanan Soutthichak | 2 December 1975 | 1 June 1989 | |
| Minister of Public Health | Souk Vongsak | 2 December 1975 | 1983 | |
| ? | 1983 | ? | ||
| Minister of Justice | Kou Souvannamethi | 2 December 1975 | 1 June 1989 | |
| Minister of Construction | Khemphon Phouipaseut | January 1982 | 1 June 1989 | |
| Minister of Material Supply and Technics | Thongsouk Saysangkhi | January 1982 | 1 June 1989 | |
| Minister of Agriculture, Forestry, and Irrigation | Khamsouk Xainyaseng | 2 December 1975 | January 1982 | |
| lnkong Mahavong | January 1982 | 1 June 1989 | ||
| Minister of Industry, Handicraft, and Forestry | Maisouk Xaisompheng | 2 December 1975 | 1 June 1989 | |
| Minister of Posts and Telecommunications | Khampheng Boupha | 2 December 1975 | 1979 | |
| ? | 1979 | ? | ||
| President of the State Planning Committee | Ma Khaikhamphithoun | 2 December 1975 | 1982 | |
| Sali Vongkhamxao | 1982 | 1 June 1989 | ||
| President of the Nationalities Committee | Nhiaveu Lobliayao | 2 December 1975 | 1 June 1989 | |
| President of the National Bank | Thongchan Ouplavan | 2 December 1975 | 1 June 1989 |