| Cabinet Name: | First Verwoerd Cabinet |
| Cabinet Number: | 1st |
| Jurisdiction: | the Republic of South Africa (since the 1961 Constitution) |
| Flag: | Flag of South Africa (1928–1982).svg |
| Flag Border: | true |
| Incumbent: | 1961–1966 |
| State Head Title: | State President |
| State Head: | Charles Robberts Swart |
| Government Head Title: | Prime Minister |
| Government Head: | Hendrik Verwoerd |
| Political Party: | National Party |
| Legislature Status: | Majority |
| Opposition Party: | United Party |
| Opposition Leader: | De Villiers Graaff |
| Election: | 1961 election |
| Previous: | Strydom |
| Successor: | Verwoerd II |
| Cabinet post | Minister | Start | End | |
|---|---|---|---|---|
| Prime Minister | 8 October 1961 | 30 March 1966 | ||
| Minister of Agriculture From 1964: Lands and land affairs | Paul Sauer D. C. H. Uys | 8 October 1961 August 1964 | August 1964 30 March 1966 | |
| Minister of Bantu Administration and Development | M. D. C. de Wet Nel | 8 October 1961 | 30 March 1966 | |
| Minister of Bantu Education | W. A. Maree | 8 October 1961 | 30 March 1966 | |
| Minister of Defense | 8 October 1961 | 30 March 1966 | ||
| Minister of Economy | 8 October 1961 | 30 March 1966 | ||
| Minister of Education, Art and Science | 8 October 1961 | 30 March 1966 | ||
| Minister of Finance | 8 October 1961 | 30 March 1966 | ||
| Minister of Foreign Affairs | 8 October 1961 9 January 1964 | 9 January 1964 30 March 1966 | ||
| Minister of Forestry | Paul Sauer W. A. Maree Frank Waring | 8 October 1961 August 1964 1965 | August 1964 1965 30 March 1966 | |
| Minister of Health | 8 October 1961 | 30 March 1966 | ||
| Minister of Housing and Community Development | 8 October 1961 | 30 March 1966 | ||
| Minister of Indian Affairs | W. A. Maree | 8 October 1961 | 30 March 1966 | |
| Minister of Information | Frank Waring | 8 October 1961 | 30 March 1966 | |
| Minister of Interior (Home Affairs) | 8 October 1961 | 30 March 1966 | ||
| Minister of Justice | 8 October 1961 | 30 March 1966 | ||
| Minister of Labour | Alfred Trollip | 8 October 1961 | 30 March 1966 | |
| Minister of Mining | Nicolaas Diederichs Jan Haak | 8 October 1961 August 1964 | August 1964 30 March 1966 | |
| Minister of Post and Telegraphs | Albert Hertzog | 8 October 1961 | 30 March 1966 | |
| Minister of Public Works | Paul Sauer Pieter Willem Botha | 8 October 1961 August 1964 | August 1964 30 March 1966 | |
| Minister of Social Security and Pensions | Jan Serfontein | 8 October 1961 | 30 March 1966 | |
| Minister of Tourism | Frank Waring | 1963 | 30 March 1966 | |
| Minister of Trade and Industry | D. C. H. Uys | 8 October 1961 | 30 March 1966 | |
| Minister of Transport | 8 October 1961 | 30 March 1966 | ||
| Minister of Water and Agricultural Technical Services | 8 October 1961 | 30 March 1966 |