| Honorific-Prefix: | Most Reverend |
| Filippo Benedetto de Sio | |
| Bishop of Boiano | |
| Church: | Catholic Church |
| Diocese: | Diocese of Boiano |
| Term: | 1641–1651 |
| Predecessor: | Pietro Filippi |
| Successor: | Petronio Veroni |
| Consecration: | 31 December 1623 |
| Consecrated By: | Denis-Simon de Marquemont |
| Birth Date: | 30 November 1585 |
| Birth Place: | Cava, Italy |
| Death Date: | 16 August 1651 |
| Death Place: | Boiano, Italy |
| Previous Post: | Bishop of Caiazzo (1623–1641) |
Filippo Benedetto de Sio (30 November 1585 - 16 August 1651) was a Roman Catholic prelate who served as Bishop of Boiano (1641–1651)[1] and Bishop of Caiazzo (1623–1641).[2]
Filippo Benedetto de Sio was born in Cava, Italy and ordained a priest in the Order of Friars Minor Conventual. On 8 December 1623, he was appointed by Pope Urban VIII as Bishop of Caiazzo. On 31 December 1623, he was consecrated bishop by Denis-Simon de Marquemont, Archbishop of Lyon, with François Boyvin de Péricard, Bishop of Evreux, and Girolamo Tantucci, Bishop of Grosseto as co-consecrators. On 21 October 1641, he was appointed by Pope Urban VIII as Bishop of Boiano. He served as Bishop of Boiano until his death on 16 August 1651.