| 50 South Sixth | |
| Alternate Names: | Dorsey & Whitney Tower |
| Location: | 50 South 6th St., Minneapolis MN |
| Start Date: | 1999 |
| Completion Date: | 2001 |
| Architect: | Skidmore, Owings & Merrill |
| Cost: | $80,000,000 |
| Floor Count: | 31 |
| Building Type: | Class A |
| Architectural Style: | postmodernism |
| Current Tenants: | Dorsey & Whitney, Deloitte |
| Height: | 404 ft (123 m) |
50 South Sixth is a 404-ft (123 m) high-rise office building in Minneapolis, Minnesota. It was completed in 2001 and has 30 floors. It is the 18th-tallest building in the city. A skyway connects this building to the 15 Building, Renaissance Square, Minneapolis City Center, and Gaviidae Common. The Minnesota Law Center once occupied this site. The 689482square feet Class A office tower is managed by Transwestern.