Fexuprazan Explained

Tradename:	Fexuclue
Atc Prefix:	None
Legal Status:	Rx in South Korea, Mexico
Synonyms:	Abeprazan; DWP14012; DWP-14012
Cas Number:	1902954-60-2
Pubchem:	122662112
Drugbank:	DB16078
Unii:	BE52S2C1QT
Chembl:	4594445
Chemspiderid:	68006985
Stdinchi:	1S/C19H17F3N2O3S/c1-23-10-12-11-24(28(25,26)15-5-3-4-13(20)8-15)18(19(12)27-2)16-7-6-14(21)9-17(16)22/h3-9,11,23H,10H2,1-2H3
Stdinchikey:	OUNXGNDVWVPCOL-UHFFFAOYSA-N
Smiles:	CNCC1=CN(C(=C1OC)C2=C(C=C(C=C2)F)F)S(=O)(=O)C3=CC=CC(=C3)F
Iupac Name:	1-[5-(2,4-Difluorophenyl)-1-(3-fluorophenyl)sulfonyl-4-methoxypyrrol-3-yl]-N-methylmethanamine
C:	19
H:	17
F:	3
N:	2
O:	3
S:	1

Fexuprazan (trade name Fexuclue) is a drug for the treatment of gastroesophageal reflux disease (GERD).^[1] It is a potassium-competitive acid blocker.^[2]

Fexuprazan is approved for use in South Korea and Mexico.^{[3] [4]}

Notes and References

1. Ramani A, Merchant A, Cash BD . Review of the clinical development of fexuprazan for gastroesophageal reflux-related disease . European Journal of Clinical Pharmacology . 79 . 8 . 1023–1029 . August 2023 . 37344679 . 10.1007/s00228-023-03521-4 . 259222741 .
2. Kim GH, Choi MG, Kim JI, Lee ST, Chun HJ, Lee KL, Choi SC, Jang JY, Lee YC, Kim JG, Kim KB, Shim KN, Sohn CI, Kim SK, Kim SG, Jang JS, Kim N, Jung HY, Park H, Huh KC, Lee KJ, Hong SJ, Baek S, Han JJ, Lee OY . Efficacy and Safety of Fexuprazan in Patients with Acute or Chronic Gastritis . Gut and Liver . 17 . 6 . 884–893 . November 2023 . 36789577 . 10651377 . 10.5009/gnl220457 .
3. Web site: 펙수클루정40밀리그램(펙수프라잔염산염) . Fexuclue tablets 40 mg (fexuprazan hydrochloride) . Korean . nedrug.mfds.go.kr .
4. News: Daewoong Pharma's GER drug gets product OK from Mexico . Korea Economic Daily . October 19, 2023 .