Fernando Enríquez de Velasco (around 1466 - 1545), 1st Duke of Medina de Rioseco, was the 5th Admiral of Castile.
Fernando Enríquez was the son of Alonso Enríquez (1435–1485) and María de Velasco. He inherited the titles from his elder brother Fadrique Enríquez when he died without children in 1538.
For his services to the Crown, he was promoted to Duke by King Charles I of Spain.
He married with María Girón, daughter of Juan Téllez-Girón, 2nd Count of Ureña, and had 5 children: