Ferdinand, Duke of Calabria (Spanish: Fernando de Aragón, Duque de Calabria) (15 December 1488 – 20 October 1550) was a Neapolitan prince who played a significant role in the Mediterranean politics of the Crown of Aragon in the early 16th century.
Born in Andria, Apulia as son of the future King Frederick and his second wife, Isabella del Balzo. He held the titles of Duke of Calabria and of Apulia.
An alliance of Louis XII of France and Ferdinand II of Aragon (Frederick's cousin) had continued the claim of Louis's predecessor, Charles VIII, to the thrones of Naples and Sicily, and in 1501 they deposed Frederick, and Naples initially went to Louis, but by 1504 a new war led to Naples' seizure by Ferdinand of Aragon.
Ferdinand was then taken prisoner by Gonzalo Fernández de Córdoba, and was moved to Barcelona as a hostage. Nevertheless, he gained the King of Aragon's friendship and later that of his grandson and successor Charles. Charles even arranged Ferdinand of Naples' marriage with his stepgrandmother, Ferdinand of Aragon's widow Germaine of Foix, in 1526. He designated them as joint viceroys of Valencia in 1537.
After Queen Germaine's death on 15 October 1536, Ferdinand married the cultivated widow Mencía de Mendoza in 1541. They became renowned for their patronage of artistic and literary works.