Fenoverine Explained

Fenoverine (INN) is an antispasmodic [also known as spasmolytics] drug,^[1] which acts by inhibiting calcium channels^[2] [much in the same way as traditional calcium channel blockers, which are used as antianginal drugs]. In the case of Fenoverine, the relaxation occurs in abdominal / intestinal smooth muscles, while in case of antianginal drugs, the relaxation occurs in coronary vessels. Notably Fenoverine does not act as an antianginal agent.

Toxicity

Fenoverine is known to cause rhabdomyolysis.^{[2] [3]}

Notes and References

1. Martínez-Vázquez MA, Vázquez-Elizondo G, González-González JA, Gutiérrez-Udave R, Maldonado-Garza HJ, Bosques-Padilla FJ . Effect of antispasmodic agents, alone or in combination, in the treatment of Irritable Bowel Syndrome: systematic review and meta-analysis . Revista de Gastroenterologia de Mexico . 77 . 2 . 82–90 . 2012 . 22672854 . 10.1016/j.rgmx.2012.04.002 . free .
2. Chariot P, Ratiney R, Le Maguet F, Fourestié V, Astier A, Gherardi R. Fenoverine-induced rhabdomyolysis . Hum Exp Toxicol . 14 . 8 . 654–656. August 1995 . 10.1177/096032719501400805 . 7576832.
3. Cho J, Na J, Bae E, Lee TW, Jang HN, Cho HS, Chang SH, Park DJ. The incidence, risk factors, and clinical outcomes of rhabdomyolysis associated with fenoverine prescription: a retrospective study in South Korea (1999-2014) . BMC Pharmacol Toxicol . 21 . 1 . 30. April 2020 . 10.1186/s40360-020-00408-3 . 32334639 . 7183697 . free .