Fenclofenac Explained

Fenclofenac is a nonsteroidal anti-inflammatory drug (NSAID) previously used in rheumatism. It has mild immunosuppressive effects[1] and may displace thyroid hormone from its binding protein.[2] [3] It can also cause lichen planus.[4]

Due to its side effects it was withdrawn from the UK and US in the 1980s.

References

  1. Spiers EM, Watson NT, Beck JS, Chapman IV, Dettmar PW . The effect of fenclofenac on the regeneration of lymphocytes in rats following total body irradiation . Int. J. Immunopharmacol. . 15 . 8 . 865–9 . November 1993 . 7902830 . 10.1016/0192-0561(93)90003-h.
  2. Allen PA, Taylor RT . Fenclofenac and thyroid function tests . Br Med J . 281 . 6255 . 1642 . December 1980 . 7448557 . 1715072 . 10.1136/bmj.281.6255.1642.
  3. Taylor R, Clark F, Griffiths ID, Weeke J . Prospective study of effect of fenclofenac on thyroid function tests . Br Med J . 281 . 6245 . 911–2 . October 1980 . 7427506 . 1714224 . 10.1136/bmj.281.6245.911.
  4. Ferguson MM, Wiesenfeld D, MacDonald DG . Oral mucosal lichenoid eruption due to fenclofenac . J Oral Med . 39 . 1 . 39–40 . 1984 . 6232357 .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Fenclofenac".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.