Fedotozine Explained

Fedotozine (INN; JO 1196 for the (-) tartrate salt) is an opioid drug which acts as a peripherally specific selective κ1-opioid receptor agonist with preference for the κ1A subtype.[1] It was under investigation for the treatment of gastrointestinal conditions like irritable bowel syndrome and functional dyspepsia and made it to phase III clinical trials,[2] [3] but ultimately development was discontinued and it was never marketed.

See also

Notes and References

  1. Delvaux M . Pharmacology and clinical experience with fedotozine . Expert Opinion on Investigational Drugs . 10 . 1 . 97–110 . January 2001 . 11116283 . 10.1517/13543784.10.1.97 . 41361900 .
  2. Barber A, Gottschlich R . Novel developments with selective, non-peptidic kappa-opioid receptor agonists . Expert Opinion on Investigational Drugs . 6 . 10 . 1351–68 . October 1997 . 15989506 . 10.1517/13543784.6.10.1351 .
  3. Lembo A . Peripheral opioids for functional GI disease: a reappraisal . Digestive Diseases . 24 . 1–2 . 91–8 . 2006 . 16699267 . 10.1159/000090312 . 29627937 .

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