| Type: | Bishop |
| Honorific-Prefix: | Most Reverend |
| Federico Mezio | |
| Bishop of Termoli | |
| Church: | Catholic Church |
| Diocese: | Diocese of Termoli |
| Term: | 1602–1612 |
| Predecessor: | Alberto Drago |
| Successor: | Camillo Moro |
| Death Date: | 1612 |
Federico Mezio (Latin: Federicus Metius) (died 1612) was a Roman Catholic prelate who served as Bishop of Termoli (1602–1612).
On 14 Jan 1602, Federico Mezio was appointed during the papacy of Pope Clement VIII as Bishop of Termoli.He served as Bishop of Termoli until his death in 1612.