FCGR2C explained

Fc fragment of IgG receptor IIc (gene/pseudogene) is a protein that in humans is encoded by the FCGR2C gene.^[1]

Function

This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants.

Further reading

• Breunis WB, van Mirre E, Bruin M, Geissler J, de Boer M, Peters M, Roos D, de Haas M, Koene HR, Kuijpers TW . Copy number variation of the activating FCGR2C gene predisposes to idiopathic thrombocytopenic purpura . Blood . 111 . 3 . 1029–38 . 2008 . 17827395 . 10.1182/blood-2007-03-079913 . free .
• Breunis WB, van Mirre E, Geissler J, Laddach N, Wolbink G, van der Schoot E, de Haas M, de Boer M, Roos D, Kuijpers TW . Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B . Hum. Mutat. . 30 . 5 . E640–50 . 2009 . 19309690 . 10.1002/humu.20997 . free .
• Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M . New genetic associations detected in a host response study to hepatitis B vaccine . Genes Immun. . 11 . 3 . 232–8 . 2010 . 20237496 . 10.1038/gene.2010.1 . free .
• Chai L, Song YQ, Zee KY, Leung WK . SNPs of Fc-gamma receptor genes and chronic periodontitis . J. Dent. Res. . 89 . 7 . 705–10 . 2010 . 20439936 . 10.1177/0022034510365444 . 30256050 .
• Niederer HA, Willcocks LC, Rayner TF, Yang W, Lau YL, Williams TN, Scott JA, Urban BC, Peshu N, Dunstan SJ, Hien TT, Phu NH, Padyukov L, Gunnarsson I, Svenungsson E, Savage CO, Watts RA, Lyons PA, Clayton DG, Smith KG . Copy number, linkage disequilibrium and disease association in the FCGR locus . Hum. Mol. Genet. . 19 . 16 . 3282–94 . 2010 . 20508037 . 2908468 . 10.1093/hmg/ddq216.
• Pandey JP . Comments on: Iwasaki et al. Fragment c gamma receptor gene polymorphisms and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians . Breast Cancer Res. Treat. . 126 . 1 . 247–8; author reply 248 . 2011 . 20978933 . 10.1007/s10549-010-1233-0 . 26361924 .
• van der Heijden J, Breunis WB, Geissler J, de Boer M, van den Berg TK, Kuijpers TW . Phenotypic variation in IgG receptors by nonclassical FCGR2C alleles . J. Immunol. . 188 . 3 . 1318–24 . 2012 . 22198951 . 10.4049/jimmunol.1003945 . free .
• Mueller M, Barros P, Witherden AS, Roberts AL, Zhang Z, Schaschl H, Yu CY, Hurles ME, Schaffner C, Floto RA, Game L, Steinberg KM, Wilson RK, Graves TA, Eichler EE, Cook HT, Vyse TJ, Aitman TJ . Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus . Am. J. Hum. Genet. . 92 . 1 . 28–40 . 2013 . 23261299 . 3542466 . 10.1016/j.ajhg.2012.11.013 .
• Makowsky R, Wiener HW, Ptacek TS, Silva M, Shendre A, Edberg JC, Portman MA, Shrestha S . FcγR gene copy number in Kawasaki disease and intravenous immunoglobulin treatment response . Pharmacogenet. Genomics . 23 . 9 . 455–62 . 2013 . 23778324 . 4400828 . 10.1097/FPC.0b013e328363686e .

Notes and References

1. Web site: Entrez Gene: Fc fragment of IgG receptor IIc (gene/pseudogene). 2017-05-24.