FCGR3B explained

FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor), also known as CD16b (Cluster of Differentiation 16b), is a human gene.^[1]

Clinical relevance

Mutations and copy-number variations in this gene have been associated to clinical cases of glomerulonephritis.^[2]

See also

• CD16
• Cluster of differentiation

Further reading

• Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV . Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination . Science . 248 . 4956 . 732–5 . May 1990 . 2139735 . 10.1126/science.2139735 . 1990Sci...248..732Q .
• Peltz GA, Grundy HO, Lebo RV, Yssel H, Barsh GS, Moore KW . Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG . Proceedings of the National Academy of Sciences of the United States of America . 86 . 3 . 1013–7 . Feb 1989 . 2521732 . 286611 . 10.1073/pnas.86.3.1013 . 1989PNAS...86.1013P . free .
• Scallon BJ, Scigliano E, Freedman VH, Miedel MC, Pan YC, Unkeless JC, Kochan JP . A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms . Proceedings of the National Academy of Sciences of the United States of America . 86 . 13 . 5079–83 . Jul 1989 . 2525780 . 297560 . 10.1073/pnas.86.13.5079 . 1989PNAS...86.5079S . free .
• Ravetch JV, Perussia B . Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions . The Journal of Experimental Medicine . 170 . 2 . 481–97 . Aug 1989 . 2526846 . 2189395 . 10.1084/jem.170.2.481 .
• Simmons D, Seed B . The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein . Nature . 333 . 6173 . 568–70 . Jun 1988 . 2967436 . 10.1038/333568a0 . 1988Natur.333..568S . 4351255 .
• Gessner JE, Grussenmeyer T, Kolanus W, Schmidt RE . The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions . The Journal of Biological Chemistry . 270 . 3 . 1350–61 . Jan 1995 . 7836402 . 10.1074/jbc.270.3.1350 . free .
• Gessner JE, Grussenmeyer T, Dumbsky M, Schmidt RE . Separate promoters from proximal and medial control regions contribute to the natural killer cell-specific transcription of the human FcgammaRIII-A (CD16-A) receptor gene . The Journal of Biological Chemistry . 271 . 48 . 30755–64 . Nov 1996 . 8940055 . 10.1074/jbc.271.48.30755 . free .
• Bux J, Stein EL, Bierling P, Fromont P, Clay M, Stroncek D, Santoso S . Characterization of a new alloantigen (SH) on the human neutrophil Fc gamma receptor IIIb . Blood . 89 . 3 . 1027–34 . Feb 1997 . 10.1182/blood.V89.3.1027 . 9028335 . free .
• Zocchi MR, Rubartelli A, Morgavi P, Poggi A . HIV-1 Tat inhibits human natural killer cell function by blocking L-type calcium channels . Journal of Immunology . 161 . 6 . 2938–43 . Sep 1998 . 10.4049/jimmunol.161.6.2938 . 9743356 .
• Sondermann P, Huber R, Oosthuizen V, Jacob U . The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex . Nature . 406 . 6793 . 267–73 . Jul 2000 . 10917521 . 10.1038/35018508 . 4306592 .
• Zhang Y, Boesen CC, Radaev S, Brooks AG, Fridman WH, Sautes-Fridman C, Sun PD . Crystal structure of the extracellular domain of a human Fc gamma RIII . Immunity . 13 . 3 . 387–95 . Sep 2000 . 11021536 . 10.1016/S1074-7613(00)00038-8 . free .
• Watanabe Y, Shimada E, Fujiwara K, Niihara H, Shimano K, Mitsunaga S, Tadokoro K, Juji T . Nucleotide sequence of a new Fc gamma receptor IIIB allele that codes for a neutrophil antigen . Tissue Antigens . 56 . 3 . 272–5 . Sep 2000 . 11034564 . 10.1034/j.1399-0039.2000.560310.x .
• Bharadwaj D, Mold C, Markham E, Du Clos TW . Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis . Journal of Immunology . 166 . 11 . 6735–41 . Jun 2001 . 11359830 . 10.4049/jimmunol.166.11.6735 . free .
• Davoine F, Lavigne S, Chakir J, Ferland C, Boulay ME, Laviolette M . Expression of FcgammaRIII (CD16) on human peripheral blood eosinophils increases in allergic conditions . The Journal of Allergy and Clinical Immunology . 109 . 3 . 463–9 . Mar 2002 . 11897993 . 10.1067/mai.2002.121952 . free .
• Fossati G, Moots RJ, Bucknall RC, Edwards SW . Differential role of neutrophil Fcgamma receptor IIIB (CD16) in phagocytosis, bacterial killing, and responses to immune complexes . Arthritis and Rheumatism . 46 . 5 . 1351–61 . May 2002 . 12115243 . 10.1002/art.10230 . free .
• Cauza K, Grassauer A, Hinterhuber G, Horvat R, Rappersberger K, Wolff K, Foedinger D . FcgammaRIII expression on cultured human keratinocytes and upregulation by interferon-gamma . The Journal of Investigative Dermatology . 119 . 5 . 1074–9 . Nov 2002 . 12445195 . 10.1046/j.1523-1747.2002.19527.x . free .
• Siriboonrit U, Tsuchiya N, Sirikong M, Kyogoku C, Bejrachandra S, Suthipinittharm P, Luangtrakool K, Srinak D, Thongpradit R, Fujiwara K, Chandanayingyong D, Tokunaga K . Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais . Tissue Antigens . 61 . 5 . 374–83 . May 2003 . 12753656 . 10.1034/j.1399-0039.2003.00047.x .
• Breij EC, van der Pol WL, van Winsen L, Jansen MD, Dijkstra CD, van de Winkel JG, Uitdehaag BM . No association of Fc gamma RIIa, Fc gamma RIIIa and Fc gamma RIIIb polymorphisms with MS . Journal of Neuroimmunology . 140 . 1–2 . 210–5 . Jul 2003 . 12864991 . 10.1016/S0165-5728(03)00207-8 . 53196500 .
• Tong Y, Jin J, Yan L, Neppert J, Marget M, Flesch BK . FCGR3B gene frequencies and FCGR3 variants in a Chinese population from Zhejiang Province . Annals of Hematology . 82 . 9 . 574–8 . Sep 2003 . 12898191 . 10.1007/s00277-003-0725-y . 21478742 .
• Tanaka S, Edberg JC, Chatham W, Fassina G, Kimberly RP . Fc gamma RIIIb allele-sensitive release of alpha-defensins: anti-neutrophil cytoplasmic antibody-induced release of chemotaxins . Journal of Immunology . 171 . 11 . 6090–6 . Dec 2003 . 14634123 . 10.4049/jimmunol.171.11.6090 . free .

Notes and References

1. Web site: Entrez Gene: FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b).
2. Aitman TJ, Dong R, Vyse TJ, Norsworthy PJ, Johnson MD, Smith J, Mangion J, Roberton-Lowe C, Marshall AJ, Petretto E, Hodges MD, Bhangal G, Patel SG, Sheehan-Rooney K, Duda M, Cook PR, Evans DJ, Domin J, Flint J, Boyle JJ, Pusey CD, Cook HT . Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans . Nature . 439 . 7078 . 851–5 . Feb 2006 . 16482158 . 10.1038/nature04489 . 2006Natur.439..851A . 4421459 .