Fasting spittle – saliva produced first thing in the morning, before breakfast – was a treatment used in folk medicine. Spittle was thought to cure many diseases. Spittle cures were usually considered to be more effective if fasting spittle was used.
An early recorded use of spittle as a cure comes from the Gospel of St Mark, believed to have been written in about 70 AD:Writing at about the same time as Mark, the Roman natural philosopher Pliny commented in his Natural History that fasting spittle was efficacious in the treatment of ophthalmia, and that the fasting spittle of a woman was particularly beneficial for treating bloodshot eyes.