Fast endophilin-mediated endocytosis explained

Fast endophilin-mediated endocytosis (FEME) is an endocytic pathway found in eukaryotic cells. It requires the activity of endophilins as well as dynamins, but does not require clathrin.[1]

In Clathrin-dependent endocytic pathways, endosomes budding from the cell membrane into the cell will form in clathrin pits, and be coated by clathrin triskelions. In FEME however, endosomes form when coated by actin, and internalise endophilin A2.

Function

Each endocytic pathway focuses on a particular component, and FEME is primarily involved in transporting receptors. These include receptors for acetylcholine and IL-2.[2]

Associated proteins

Notes and References

  1. Casamento A, Boucrot E . Molecular mechanism of Fast Endophilin-Mediated Endocytosis . The Biochemical Journal . 477 . 12 . 2327–2345 . June 2020 . 32589750 . 7319585 . 10.1042/bcj20190342 .
  2. Rennick JJ, Johnston AP, Parton RG . Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics . Nature Nanotechnology . 16 . 3 . 266–276 . March 2021 . 33712737 . 10.1038/s41565-021-00858-8 . 2021NatNa..16..266R . 232215301 . free .
  3. Boucrot . Emmanuel . Ferreira . Antonio P. A. . Almeida-Souza . Leonardo . Debard . Sylvain . Vallis . Yvonne . Howard . Gillian . Bertot . Laetitia . Sauvonnet . Nathalie . McMahon . Harvey T. . January 2015 . Endophilin marks and controls a clathrin-independent endocytic pathway . Nature . en . 517 . 7535 . 460–465 . 10.1038/nature14067 . 25517094 . 2015Natur.517..460B . 4470056 . 0028-0836 . 2022-10-11 . 2022-10-12 . https://web.archive.org/web/20221012092339/https://www.nature.com/articles/nature14067 . live .

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