Fasiplon Explained

Fasiplon (RU 33203) is a nonbenzodiazepine anxiolytic drug from the imidazopyrimidine family of drugs.

Fasiplon binds strongly to benzodiazepine sites on the GABAA receptor and has similar anxiolytic effects in animals, but with less sedative or muscle relaxant action.[1] It was developed by a team at Roussel Uclaf in the 1990s[2]

References

  1. Tully WR, Gardner CR, Gillespie RJ, Westwood R . 2-(oxadiazolyl)- and 2-(thiazolyl)imidazo[1,2-a]pyrimidines as agonists and inverse agonists at benzodiazepine receptors . Journal of Medicinal Chemistry . 34 . 7 . 2060–7 . July 1991 . 1648620 . 10.1021/jm00111a021.
  2. US Patent 5869481 Anticonvulsive 1-ar(alk)ylimidazolin-2-ones and process for making

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