Famprofazone Explained

Famprofazone (Gewodin, Gewolen) is a nonsteroidal anti-inflammatory agent (NSAID) of the pyrazolone series which is available over-the-counter in some countries such as Taiwan.^{[1] [2] [3]} It has analgesic, anti-inflammatory, and antipyretic effects.^{[1] [2]} Famprofazone has been known to produce methamphetamine as an active metabolite, with 15–20% of an oral dose being converted to it.^{[4] [5]} As a result, famprofazone has occasionally been implicated in causing positives on drug tests for amphetamines.^[3]

See also

• Difenamizole
• Morazone

Notes and References

1. Book: Swiss Pharmaceutical Society . Index Nominum 2000: International Drug Directory (Book with CD-ROM) . Medpharm Scientific Publishers . Boca Raton . 2000 . 1932 . 3-88763-075-0 .
2. Book: Hall JA, Morton I . Concise dictionary of pharmacological agents: properties and synonyms . Kluwer Academic . 1999 . 342 . 0-7514-0499-3 .
3. Chan KH, Hsu MC, Tseng CY, Chu WL . Famprofazone use can be misinterpreted as methamphetamine abuse . Journal of Analytical Toxicology . 34 . 6 . 347–353 . 2010 . 20663288 . 10.1093/jat/34.6.347 .
4. Oh ES, Hong SK, Kang GI . Plasma and urinary concentrations of methamphetamine after oral administration of famprofazone to man . Xenobiotica; the Fate of Foreign Compounds in Biological Systems . 22 . 3 . 377–384 . March 1992 . 1496827 . 10.3109/00498259209046649 .
5. Shin HS, Park BB, Choi SN, Oh JJ, Hong CP, Ryu H . Identification of new urinary metabolites of famprofazone in humans . Journal of Analytical Toxicology . 22 . 1 . 55–60 . 1998 . 9491970 . 10.1093/jat/22.1.55 . free .