Famiraprinium Explained

Famiraprinium (also known as SR-95103) is a GABAA receptor antagonist used in scientific research.[1]

It antagonizes certain GABAA receptors with an inhibition constant of 2.2 μM.[2]

Effects

Like other GABA antagonists, it triggers epilepsy-like symptoms. These effects can be antagonized by GABAA agonists like muscimol, proving it is an antagonist.[3]

Notes and References

  1. Schmitt . P. . Di Scala . G. . Brandao . M. L. . Karli . P. . 1985-11-05 . Behavioral effects of microinjections of SR 95103, a new GABA-A antagonist, into the medial hypothalamus or the mesencephalic central gray . European Journal of Pharmacology . 117 . 2 . 149–158 . 10.1016/0014-2999(85)90599-0 . 0014-2999 . 3000802.
  2. Chambon . J. P. . Feltz . P. . Heaulme . M. . Restle . S. . Schlichter . R. . Biziere . K. . Wermuth . C. G. . March 1985 . An arylaminopyridazine derivative of gamma-aminobutyric acid (GABA) is a selective and competitive antagonist at the GABAA receptor site . Proceedings of the National Academy of Sciences of the United States of America . 82 . 6 . 1832–1836 . 10.1073/pnas.82.6.1832 . free . 0027-8424 . 2984669.
  3. Santucci . V. . Fournier . M. . Chambon . J. P. . Biziere . K. . 1985-08-15 . Electroencephalographic study of SR 95103, a GABAA antagonist: interaction with inhibitory amino acids and muscimol . European Journal of Pharmacology . 114 . 2 . 219–222 . 10.1016/0014-2999(85)90630-2 . 0014-2999 . 2995080.

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