Family with sequence similarity 19 member A4, C-C motif chemokine like explained

Family with sequence similarity 19 member A4, C-C motif chemokine like is a protein that in humans is encoded by the FAM19A4 gene.^[1]

Function

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011].

Further reading

• Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y . Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals . Am. J. Hypertens. . 23 . 1 . 70–7 . 2010 . 19851296 . 10.1038/ajh.2009.190 . free .
• Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y . Association of genetic variants with hemorrhagic stroke in Japanese individuals . Int. J. Mol. Med. . 25 . 4 . 649–56 . 2010 . 20198315 . 10.3892/ijmm_00000388. free .
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• Wang W, Li T, Wang X, Yuan W, Cheng Y, Zhang H, Xu E, Zhang Y, Shi S, Ma D, Han W . FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages . Cell. Mol. Immunol. . 12 . 5 . 615–24 . 2015 . 25109685 . 4579646 . 10.1038/cmi.2014.61 .
• De Strooper LM, Meijer CJ, Berkhof J, Hesselink AT, Snijders PJ, Steenbergen RD, Heideman DA . Methylation analysis of the FAM19A4 gene in cervical scrapes is highly efficient in detecting cervical carcinomas and advanced CIN2/3 lesions . Cancer Prev Res (Phila) . 7 . 12 . 1251–7 . 2014 . 25281488 . 10.1158/1940-6207.CAPR-14-0237 . free .
• Luttmer R, De Strooper LM, Berkhof J, Snijders PJ, Dijkstra MG, Uijterwaal MH, Steenbergen RD, van Kemenade FJ, Rozendaal L, Helmerhorst TJ, Verheijen RH, Ter Harmsel WA, Van Baal WM, Graziosi PG, Quint WG, Heideman DA, Meijer CJ . Comparing the performance of FAM19A4 methylation analysis, cytology and HPV16/18 genotyping for the detection of cervical (pre)cancer in high-risk HPV-positive women of a gynecologic outpatient population (COMETH study) . Int. J. Cancer . 138 . 4 . 992–1002 . 2016 . 26317579 . 10.1002/ijc.29824 . free .
• De Strooper LM, Verhoef VM, Berkhof J, Hesselink AT, de Bruin HM, van Kemenade FJ, Bosgraaf RP, Bekkers RL, Massuger LF, Melchers WJ, Steenbergen RD, Snijders PJ, Meijer CJ, Heideman DA . Validation of the FAM19A4/mir124-2 DNA methylation test for both lavage- and brush-based self-samples to detect cervical (pre)cancer in HPV-positive women . Gynecol. Oncol. . 141 . 2 . 341–347 . 2016 . 26921784 . 4851217 . 10.1016/j.ygyno.2016.02.012 .

Notes and References

1. Web site: Entrez Gene: Family with sequence similarity 19 member A4, C-C motif chemokine like. 2017-12-09.