| Season Number: | 16 |
| Bgcolor: |
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| Num Episodes: | 20 |
| Network: | Fox |
| Episode List: | List of Family Guy episodes |
The sixteenth season of Family Guy aired on Fox in the United States from October 1, 2017, to May 20, 2018.
The series follows the dysfunctional Griffin family, consisting of father Peter, mother Lois, daughter Meg, son Chris, baby Stewie, and the family dog Brian, who reside in their hometown of Quahog. The executive producers for the sixteenth production season are Seth MacFarlane, Richard Appel, Alec Sulkin, Steve Callaghan, Danny Smith, and Kara Vallow. Sulkin returns after a two-season absence as the new showrunner for the series, replacing previous showrunner Callaghan. Appel continues to serve as showrunner alongside Sulkin.
The season features guest appearances from Bill Maher, Sir Ian McKellen, Kristen Bell, Louis C.K., and Modern Family cast members Ty Burrell, Julie Bowen, and Sofía Vergara.
The season also marks the final appearances of Adam West and Carrie Fisher following their deaths, as well as the show's 300th episode ("Dog Bites Bear").
As of season sixteen, the series' first-run cable syndication rights have switched from Adult Swim and TBS, who had premiered the first fifteen seasons, over to Disney-owned Freeform and FXX, who will continue to premiere new episodes on cable with the coming seasons. Freeform and FXX began exclusively broadcasting the first fifteen seasons starting in September 2021 when Family Guy officially went off Adult Swim and TBS.__TOC__
Fox celebrated the series' 300th episode with a character customization website titled familyguyyourself.com in which users could create versions of themselves in the show's art style.