Frizzled-9 Explained

Frizzled-9 (Fz-9) is a protein that in humans is encoded by the FZD9 gene.^{[1] [2] [3]} Fz-9 has also been designated as CD349 (cluster of differentiation 349).

Function

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.

Further reading

• Datta DV . Viral hepatitis (Chandigarh study) . The Journal of the Association of Physicians of India . 25 . 5 . 325–30 . May 1977 . 914765 .
• Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS . Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action . Proceedings of the National Academy of Sciences of the United States of America . 94 . 13 . 6770–5 . Jun 1997 . 9192640 . 21233 . 10.1073/pnas.94.13.6770 . 1997PNAS...94.6770F . free .
• Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K . A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals . Proceedings of the National Academy of Sciences of the United States of America . 95 . 17 . 10164–9 . Aug 1998 . 9707618 . 21479 . 10.1073/pnas.95.17.10164 . 1998PNAS...9510164T . free .
• Karasawa T, Yokokura H, Kitajewski J, Lombroso PJ . Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling . The Journal of Biological Chemistry . 277 . 40 . 37479–86 . Oct 2002 . 12138115 . 10.1074/jbc.M205658200 . free .
• Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y . Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R) . Ophthalmic Genetics . 25 . 2 . 81–90 . Jun 2004 . 15370539 . 10.1080/13816810490514270 . 32817238 .
• Winn RA, Marek L, Han SY, Rodriguez K, Rodriguez N, Hammond M, Van Scoyk M, Acosta H, Mirus J, Barry N, Bren-Mattison Y, Van Raay TJ, Nemenoff RA, Heasley LE . Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation . The Journal of Biological Chemistry . 280 . 20 . 19625–34 . May 2005 . 15705594 . 10.1074/jbc.M409392200 . free .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Winn RA, Van Scoyk M, Hammond M, Rodriguez K, Crossno JT, Heasley LE, Nemenoff RA . Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma . The Journal of Biological Chemistry . 281 . 37 . 26943–50 . Sep 2006 . 16835228 . 10.1074/jbc.M604145200 . free .

External links

• Web site: Frizzled Receptors: FZD₉ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-04 . 2012-03-19 . https://web.archive.org/web/20120319220800/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3067 . dead .

Notes and References

1. Wang YK, Samos CH, Peoples R, Pérez-Jurado LA, Nusse R, Francke U . A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23 . Human Molecular Genetics . 6 . 3 . 465–72 . Mar 1997 . 9147651 . 10.1093/hmg/6.3.465 . free .
2. Wang YK, Spörle R, Paperna T, Schughart K, Francke U . Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome . Genomics . 57 . 2 . 235–48 . Apr 1999 . 10198163 . 10.1006/geno.1999.5773 . free .
3. Web site: Entrez Gene: FZD9 frizzled homolog 9 (Drosophila).